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Here, it is shown that TRPV2 in myeloid cells facilitates virus penetration by promoting the tension and mobility of cell membrane through the Ca\n                    <jats:sup>2+<\/jats:sup>\n                    \u2010LRMDA axis. Knockout of TRPV2 in myeloid cells or inhibition of TRPV2 channel activity suppresses viral infection and protects mice from herpes simplex virus 1 (HSV\u20101) and vesicular stomatitis virus (VSV) infection. Reconstitution of TRPV2 but not the Ca\n                    <jats:sup>2+<\/jats:sup>\n                    \u2010impermeable mutant TRPV2\n                    <jats:sup>E572Q<\/jats:sup>\n                    into\n                    <jats:italic>LyZ2<\/jats:italic>\n                    \u2010Cre;\n                    <jats:italic>Trpv2<\/jats:italic>\n                    <jats:sup>fl\/fl<\/jats:sup>\n                    bone marrow\u2010derived dendritic cells (BMDCs) restores viral infection. Mechanistically, knockout of TRPV2 in myeloid cells inhibits the tension and mobility of cell membrane and the penetration of viruses, which is restored by reconstitution of TRPV2 but not TRPV2\n                    <jats:sup>E572Q<\/jats:sup>\n                    . In addition, knockout of TRPV2 leads to downregulation of\n                    <jats:italic>Lrmda<\/jats:italic>\n                    in BMDCs and BMDMs, and knockdown of\n                    <jats:italic>Lrmda<\/jats:italic>\n                    significantly downregulates the mobility and tension of cell membrane and inhibits viral infections in\n                    <jats:italic>Trpv2<\/jats:italic>\n                    <jats:sup>fl\/fl<\/jats:sup>\n                    but not\n                    <jats:italic>LyZ2<\/jats:italic>\n                    \u2010Cre;\n                    <jats:italic>Trpv2<\/jats:italic>\n                    <jats:sup>fl\/fl<\/jats:sup>\n                    BMDCs. Consistently, complement of LRMDA into\n                    <jats:italic>LyZ2<\/jats:italic>\n                    \u2010Cre;\n                    <jats:italic>Trpv2<\/jats:italic>\n                    <jats:sup>fl\/fl<\/jats:sup>\n                    BMDCs partially restores the tension and mobility of cell membrane and promotes viral penetration and infection. These findings characterize a previously unknown function of myeloid TRPV2 in facilitating viral infection though the Ca2\n                    <jats:sup>+<\/jats:sup>\n                    \u2010LRMDA axis.\n                  <\/jats:p>","DOI":"10.1002\/advs.202202857","type":"journal-article","created":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T22:50:53Z","timestamp":1666219853000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["The Transient Receptor Potential Vanilloid 2 (TRPV2) Channel Facilitates Virus Infection Through the Ca\n                    <sup>2+<\/sup>\n                    \u2010LRMDA Axis in Myeloid Cells"],"prefix":"10.1002","volume":"9","author":[{"given":"Yu\u2010Yao","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Gastrointestinal Surgery College of Life Sciences Zhongnan Hospital of Wuhan University Wuhan University  Wuhan 430071 China"},{"name":"Department of 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