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However, the photosensitization efficiencies are still finite by the unilateral improvement of excited\u2010state intersystem crossing (ISC) via heavy\u2010atom\u2010effect, since the upconverted efficiency also plays a decisive role in upconverted photosensitization. Herein, a NIR light initiated one\u2010photon upconversion heavy\u2010atom\u2010free small molecule system is reported. The meso\u2010rotatable anthracene in pentamethine cyanine (Cy5) is demonstrated to enrich the populations in high vibrational\u2013rotational energy levels and subsequently improve the hot\u2010band absorption (HBA) efficiency. Moreover, the spin\u2013orbit charge transfer intersystem crossing (SOCT\u2010ISC) caused by electron donated anthracene can further amplify the triplet yield. Benefiting from the above two aspects, the\n                    <jats:sup>1<\/jats:sup>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    generation significantly increases with over 2\u2010fold improved performance compared with heavy\u2010atom\u2010modified method under upconverted light excitation, which obtains efficient in vivo phototheranostic results and provides new opportunities for other applications such as photocatalysis and fine chemical synthesis.\n                  <\/jats:p>","DOI":"10.1002\/advs.202202885","type":"journal-article","created":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T15:29:27Z","timestamp":1662996567000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["An Approach to Developing Cyanines with Upconverted Photosensitive Efficiency Enhancement for Highly Efficient NIR Tumor Phototheranostics"],"prefix":"10.1002","volume":"9","author":[{"given":"Xueze","family":"Zhao","sequence":"first","affiliation":[{"name":"State Key Laboratory of Fine Chemicals Frontiers Science Center for Smart Materials Oriented Chemical Engineering Dalian University of Technology  Dalian 116024 P. 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