{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T03:42:10Z","timestamp":1791517330970,"version":"4.3.4"},"reference-count":86,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,2,19]],"date-time":"2023-02-19T00:00:00Z","timestamp":1676764800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,2,19]],"date-time":"2023-02-19T00:00:00Z","timestamp":1676764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["CCF\u20101837131"],"award-info":[{"award-number":["CCF\u20101837131"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["CPS\/CNS\u20101453860"],"award-info":[{"award-number":["CPS\/CNS\u20101453860"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["MCB\u20101936775"],"award-info":[{"award-number":["MCB\u20101936775"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["CNS\u20101932620"],"award-info":[{"award-number":["CNS\u20101932620"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000183","name":"Army Research Office","doi-asserted-by":"publisher","award":["W911NF\u201017\u20101\u20100076"],"award-info":[{"award-number":["W911NF\u201017\u20101\u20100076"]}],"id":[{"id":"10.13039\/100000183","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chronic obstructive pulmonary disease (COPD) is one of the leading causes of death worldwide. Current COPD diagnosis (i.e., spirometry) could be unreliable because the test depends on an adequate effort from the tester and testee. Moreover, the early diagnosis of COPD is challenging. The authors address COPD detection by constructing two novel physiological signals datasets (4432 records from 54 patients in the WestRo COPD dataset and 13824 medical records from 534 patients in the WestRo Porti COPD dataset). The authors demonstrate their complex coupled fractal dynamical characteristics and perform a fractional\u2010order dynamics deep learning analysis to diagnose COPD. The authors found that the fractional\u2010order dynamical modeling can extract distinguishing signatures from the physiological signals across patients with all COPD stages\u2014from stage 0 (healthy) to stage 4 (very severe). They use the fractional signatures to develop and train a deep neural network that predicts COPD stages based on the input features (such as thorax breathing effort, respiratory rate, or oxygen saturation). The authors show that the fractional dynamic deep learning model (FDDLM) achieves a COPD prediction accuracy of 98.66% and can serve as a robust alternative to spirometry. The FDDLM also has high accuracy when validated on a dataset with different physiological signals.<\/jats:p>","DOI":"10.1002\/advs.202203485","type":"journal-article","created":{"date-parts":[[2023,2,19]],"date-time":"2023-02-19T22:37:28Z","timestamp":1676846248000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Fractional Dynamics Foster Deep Learning of COPD Stage Prediction"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6411-7441","authenticated-orcid":false,"given":"Chenzhong","family":"Yin","sequence":"first","affiliation":[{"name":"Ming Hsieh Department of Electrical and Computer Engineering University of Southern California  Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihai","family":"Udrescu","sequence":"additional","affiliation":[{"name":"Department of Computer and Information Technology Politehnica University of Timisoara  2 Vasile Parvan Blvd. Timi\u015foara 300223 Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaurav","family":"Gupta","sequence":"additional","affiliation":[{"name":"Ming Hsieh Department of Electrical and Computer Engineering University of Southern California  Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxi","family":"Cheng","sequence":"additional","affiliation":[{"name":"Ming Hsieh Department of Electrical and Computer Engineering University of Southern California  Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrei","family":"Lihu","sequence":"additional","affiliation":[{"name":"Department of Computer and Information Technology Politehnica University of Timisoara  2 Vasile Parvan Blvd. Timi\u015foara 300223 Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucretia","family":"Udrescu","sequence":"additional","affiliation":[{"name":"Department I \u2013 Drug Analysis \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy Timi\u015foara  2 Eftimie Murgu Sq. Timi\u015foara 300041 Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2118-0816","authenticated-orcid":false,"given":"Paul","family":"Bogdan","sequence":"additional","affiliation":[{"name":"Ming Hsieh Department of Electrical and Computer Engineering University of Southern California  Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Mannino","sequence":"additional","affiliation":[{"name":"College of Medicine University of Kentucky  Lexington KY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Mihaicuta","sequence":"additional","affiliation":[{"name":"Department of Pulmonology Center for Research and Innovation in Precision Medicine of Respiratory Diseases, \u201cVictor Babes\u201d University of Medicine and Pharmacy  2 Eftimie Murgu Sq. Timi\u015foara 300041 Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,19]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.17599"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-3022"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61728-0"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201204-0596PP"},{"key":"e_1_2_9_5_1","author":"Agust\u00ed A.","year":"2018","journal-title":"Lancet Respir. Med."},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01359-2015"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.04.00014304"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2405010"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01170-2015"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2466-14-163"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1109\/JBHI.2017.2713988"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2010.156372"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00102509"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01034-2017"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00171614"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygeno.2016.01.004"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-37186-2"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.3289"},{"key":"e_1_2_9_19_1","first-page":"2178","volume-title":"Engineering in Medicine and Biology Society (EMBC), 2012 Annual International Conference of the IEEE","author":"Ding H.","year":"2012"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12911-015-0171-5"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-013-0924-2"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1137\/1010093"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004249900135"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4371(02)01383-3"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevE.49.1685"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1114\/1.1481053"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/33.7.943"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physa.2014.09.002"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.01704"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physa.2008.04.023"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2012.00141"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-019-0686-2"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3795(82)90112-4"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201710-2140CI"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2014.00104"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201501-0157OC"},{"key":"e_1_2_9_37_1","volume":"4","author":"Bogdan P.","year":"2014","journal-title":"Sci. Rep."},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1109\/cdc45484.2021.9683076"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.23919\/ACC.2018.8430866"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/383323a0"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1209\/epl\/i1999-00525-0"},{"key":"e_1_2_9_42_1","first-page":"642","volume-title":"Design, Automation & Test in Europe Conference & Exhibition (DATE), 2016","author":"Xue Y.","year":"2016"},{"key":"e_1_2_9_43_1","first-page":"17","volume-title":"Proceedings of the ninth IEEE\/ACM\/IFIP international conference on hardware\/software codesign and system synthesis","author":"Ghorbani M.","year":"2013"},{"key":"e_1_2_9_44_1","doi-asserted-by":"crossref","unstructured":"Y.Xue S.Pequito J. R.Coelho P.Bogdan G. J.Pappas inCommunication Control and Computing (Allerton) 2016 54th Annual Allerton Conference on IEEE 2016 pp.1181\u20131188.","DOI":"10.1109\/ALLERTON.2016.7852369"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1145\/3055004.3055017"},{"key":"e_1_2_9_46_1","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1007\/978-3-030-61725-7_35","volume-title":"International Conference on Dynamic Data Driven Application Systems","author":"Yin C.","year":"2020"},{"key":"e_1_2_9_47_1","unstructured":"A.Greaves\u2010Tunnell Z.Harchaoui inInternational Conference on Machine Learning PMLR2019 pp.2394\u20132403."},{"key":"e_1_2_9_48_1","unstructured":"J.Cheng L.Dong M.Lapata arXiv preprint arXiv:1601.067332016."},{"key":"e_1_2_9_49_1","volume-title":"International Conference on Computational Intelligence for Modelling, Control and Automation and International Conference on Intelligent Agents, Web Technologies and Internet Commerce (CIMCA\u2010IAWTIC)","author":"Dzielinski A.","year":"2005"},{"key":"e_1_2_9_50_1","first-page":"275","volume-title":"Proceedings of the 9th ACM\/IEEE International Conference on Cyber\u2010Physical Systems, ICCPS '18","author":"Gupta G.","year":"2018"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-18564-8"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14539"},{"key":"e_1_2_9_53_1","volume-title":"Deep Learning (Adaptive Computation and Machine Learning)","author":"Ian G.","year":"2016"},{"key":"e_1_2_9_54_1","first-page":"335","volume":"15","author":"Raskutti G.","year":"2014","journal-title":"J. Mach. Learn. Res."},{"key":"e_1_2_9_55_1","first-page":"270","volume-title":"International Conference on Artificial Neural Networks","author":"Tan C.","year":"2018"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/resp.13107"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(19)30198-5"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9113688"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2014-206590"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60647-X"},{"key":"e_1_2_9_61_1","first-page":"116","volume":"1","author":"Rennard S.","year":"2015","journal-title":"BRN Rev"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2007.03013.x"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2012.04.010"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevE.79.041920"},{"key":"e_1_2_9_65_1","first-page":"31","volume":"77","author":"Soumagne T.","year":"2020","journal-title":"Respir. Med. Res."},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-1059-1"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00034805"},{"key":"e_1_2_9_68_1","first-page":"265","volume-title":"12th USENIX Symposium on Operating Systems Design and Implementation (OSDI 16)","author":"Abadi M.","year":"2016"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201908-1590ST"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.5.2101039"},{"key":"e_1_2_9_71_1","first-page":"321","volume":"26","author":"Miller M.","year":"2005","journal-title":"Eur. Respir. J."},{"key":"e_1_2_9_72_1","first-page":"58","volume":"44","author":"Glover R.","year":"2014","journal-title":"Eur. Respir. J."},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200204-347OC"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00116814"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S183736"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201605-418OC"},{"key":"e_1_2_9_77_1","doi-asserted-by":"crossref","unstructured":"M.Hegewald H.Gallo O.Linares R.Jensen A.Morris Accuracy of spirometers used in primary care 2015.","DOI":"10.1183\/13993003.congress-2015.PA1577"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200703-456SO"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S136711"},{"key":"e_1_2_9_80_1","first-page":"13","volume":"11","author":"Jones P. W.","year":"2016","journal-title":"Int. J. Chronic Obstruct. Pulm. Dis."},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41533-021-00226-y"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S91742"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.14930"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61290-3"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00208613"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(17)30119-4"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202203485","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.202203485","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202203485","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202203485","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T23:21:39Z","timestamp":1759792899000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202203485"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,19]]},"references-count":86,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1002\/advs.202203485"],"URL":"https:\/\/doi.org\/10.1002\/advs.202203485","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,19]]},"assertion":[{"value":"2022-06-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2203485"}}