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Among these, chemotherapy\u2010induced hepatotoxicity and cardiotoxicity are the main causes of death of cancer patients. Chemotherapy\u2010induced cardiotoxicity even creates a new discipline termed \u201ccardio\u2010oncology\u201d. Therefore, relieving toxicities induced by chemotherapy has become a key issue for improving the survival and quality of life in cancer patients. In this work, mesenchymal stem cell exosomes with the \u201cG\u2010C\u201d abundant tetrahedral DNA nanostructure (TDN) are modified to form a decoy exosome (Exo\u2010TDN). Exo\u2010TDN reduces DOX\u2010induced hepatotoxicity as the \u201cG\u2010C\u201d base pairs scavenge DOX. Furthermore, Exo\u2010TDN with cardiomyopathic peptide (Exo\u2010TDN\u2010PCM) is engineered for specific targeting to cardiomyocytes. Injection of Exo\u2010TDN\u2010PCM significantly reduces DOX\u2010induced cardiotoxicity. Interestingly, Exo\u2010TDN\u2010PCM can also promote macrophage polarization into the M2 type for tissue repair. In addition, those decoy exosomes do not affect the anticancer effects of DOX. This decoy exosome strategy serves as a promising therapy to reduce chemo\u2010induced toxicity.<\/jats:p>","DOI":"10.1002\/advs.202203505","type":"journal-article","created":{"date-parts":[[2022,9,4]],"date-time":"2022-09-04T15:01:46Z","timestamp":1662303706000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Decoy Exosomes Offer Protection Against Chemotherapy\u2010Induced Toxicity"],"prefix":"10.1002","volume":"9","author":[{"given":"Miao","family":"Fan","sequence":"first","affiliation":[{"name":"Affiliated Dongguan Hospital Southern Medical University  Dongguan 523059 China"},{"name":"College of Chemistry &amp; Environmental Science Chemical Biology Key Laboratory of Hebei Province Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education Hebei University  Baoding 071002 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Li","sequence":"additional","affiliation":[{"name":"College of Chemistry &amp; Environmental Science Chemical Biology Key Laboratory of Hebei Province Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education Hebei University  Baoding 071002 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deliang","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Cardiology The First Affiliated Hospital of Zhengzhou University  Zhengzhou Henan 450052 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoshuo","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Chemistry &amp; Environmental Science Chemical Biology Key Laboratory of Hebei Province Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education Hebei University  Baoding 071002 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huifang","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Science Key Laboratory of Pharmaceutical Quality Control of Hebei Province Hebei University  Baoding 071002 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dashuai","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Molecular Biomedical Sciences and Comparative Medicine Institute North Carolina State University  Raleigh NC 27607 USA"},{"name":"Joint Department of Biomedical Engineering University of North Carolina at Chapel Hill and North Carolina State University  Raleigh NC 27695 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenzhen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Molecular Biomedical Sciences and Comparative Medicine Institute North Carolina State University  Raleigh NC 27607 USA"},{"name":"Joint Department of Biomedical Engineering University of North Carolina at Chapel Hill and North Carolina State University  Raleigh NC 27695 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanya","family":"Li","sequence":"additional","affiliation":[{"name":"Affiliated Dongguan Hospital Southern Medical University  Dongguan 523059 China"},{"name":"Guangdong Provincial Key Laboratory of Cardiac Function and Microcirculation  Guangdong 510515 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen D.","family":"Popowski","sequence":"additional","affiliation":[{"name":"Department of Molecular Biomedical Sciences and Comparative Medicine Institute North Carolina State University  Raleigh NC 27607 USA"},{"name":"Joint Department of Biomedical Engineering University of North Carolina at Chapel Hill and North Carolina State University  Raleigh NC 27695 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caiwen","family":"Ou","sequence":"additional","affiliation":[{"name":"Affiliated Dongguan Hospital Southern Medical University  Dongguan 523059 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaihan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Chemistry The University of Manchester  Manchester M13 9PL UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinchao","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Chemistry &amp; 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