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Here, a novel MRI method assesses the feasibility of identifying normally grown and FGR fetuses in sheep and is then applied to humans. MRI scans are performed in pregnant ewes at 110 and 140 days (term = 150d) gestation and in pregnant women at 28<jats:sup>+3<\/jats:sup>\u00a0\u00b1\u00a02<jats:sup>+5<\/jats:sup> weeks to measure feto\u2010placental SO<jats:sub>2<\/jats:sub>. Birth weight is collected and, in sheep, fetal blood SO<jats:sub>2<\/jats:sub> is measured with a blood gas analyzer (BGA). Fetal arterial SO<jats:sub>2<\/jats:sub> measured by BGA predicts fetal birth weight in sheep and distinguishes between fetuses that are normally grown, small for gestational age, and FGR. MRI feto\u2010placental SO<jats:sub>2<\/jats:sub> in late gestation is related to fetal blood SO<jats:sub>2<\/jats:sub> measured by BGA and body weight. In sheep, MRI feto\u2010placental SO<jats:sub>2<\/jats:sub> in mid\u2010gestation is related to fetal SO<jats:sub>2<\/jats:sub> later in gestation. MRI feto\u2010placental SO<jats:sub>2<\/jats:sub> distinguishes between normally grown and FGR fetuses, as well as distinguishing FGR fetuses with and without normal Doppler in humans. Thus, a multi\u2010compartment placental MRI model detects low placental SO<jats:sub>2<\/jats:sub> and distinguishes between small hypoxemic fetuses and normally grown fetuses.<\/jats:p>","DOI":"10.1002\/advs.202203738","type":"journal-article","created":{"date-parts":[[2022,8,28]],"date-time":"2022-08-28T21:40:42Z","timestamp":1661722842000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Placental MRI Predicts Fetal Oxygenation and Growth Rates in Sheep and Human Pregnancy"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8846-3573","authenticated-orcid":false,"given":"Dimitra","family":"Flouri","sequence":"first","affiliation":[{"name":"School of Biomedical Engineering and Imaging Sciences King's College London  London SE1 7EU UK"},{"name":"Department of Medical Physics and Biomedical Engineering University College London  London WC1E 6BT UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack R. 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