{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:58:39Z","timestamp":1787619519017,"version":"build-2736575974"},"reference-count":45,"publisher":"Wiley","issue":"31","license":[{"start":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T00:00:00Z","timestamp":1664496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22175062"],"award-info":[{"award-number":["22175062"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010083","name":"Hunan Provincial Innovation Foundation for Postgraduate","doi-asserted-by":"publisher","award":["CX20210427"],"award-info":[{"award-number":["CX20210427"]}],"id":[{"id":"10.13039\/501100010083","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Excessive production of hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S) plays a crucial role in the progress of colon cancer. Construction of tumor\u2010specific H\n                    <jats:sub>2<\/jats:sub>\n                    S\u2010activated smart nanoplatform with controllable biodegradation is of great significance for precise and sustainable treatment of colon cancer. Herein, an endogenous H\n                    <jats:sub>2<\/jats:sub>\n                    S triggered Co\u2010doped polyoxometalate (POM\u2010Co) cluster with self\u2010adjustable size, controlled biodegradation, and sustainable cyclic depletion of H\n                    <jats:sub>2<\/jats:sub>\n                    S\/glutathione (GSH) is designed for synergistic enhanced tumor\u2010specific photothermal and chemodynamic therapy. The designed POM\u2010Co nanocluster holds H\n                    <jats:sub>2<\/jats:sub>\n                    S responsive \u201cturn\u2010on\u201d photothermal property in colon cancer via self\u2010assembling to form large\u2010sized POM\u2010CoS, enhancing the accumulation at tumor sites. Furthermore, the formed POM\u2010CoS can gradually biodegrade, resulting in release of Co\n                    <jats:sup>2+<\/jats:sup>\n                    and Mo\n                    <jats:sup>6+<\/jats:sup>\n                    for Co(II)\u2010catalyzed \u2022OH production and Russell mechanism\u2010enabled\n                    <jats:sup>1<\/jats:sup>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    generation with GSH consumption, respectively. More importantly, the degraded POM\u2010CoS is reactivated by endogenous H\n                    <jats:sub>2<\/jats:sub>\n                    S for recyclable and sustainable consumption of H\n                    <jats:sub>2<\/jats:sub>\n                    S and GSH, resulting in tumor\u2010specific photothermal\/chemodynamic continuous therapy. Therefore, this study provides an opportunity of designing tumor microenvironment\u2010driven nanoprobes with controllable biodegradation for precise and sustainable anti\u2010tumor therapy.\n                  <\/jats:p>","DOI":"10.1002\/advs.202203902","type":"journal-article","created":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T22:30:54Z","timestamp":1664577054000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Recyclable Endogenous H\n                    <sub>2<\/sub>\n                    S Activation of Self\u2010Assembled Nanoprobe with Controllable Biodegradation for Synergistically Enhanced Colon Cancer\u2010Specific Therapy"],"prefix":"10.1002","volume":"9","author":[{"given":"Junqing","family":"Huang","sequence":"first","affiliation":[{"name":"School of Physics and Electronics Key Laboratory of Low\u2010dimensional Quantum Structures and Quantum Control of the Ministry of Education Synergetic 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