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This study is the first to identify a novel circular RNA (circRNA), circTBC1D14, whose expression is significantly upregulated in TNBC. The authors confirm that high circTBC1D14 expression is associated with a poor prognosis in patients with breast cancer. circTBC1D14\u2010associated mass spectrometry and RNA\u2010binding protein\u2010related bioinformatics strategies indicate that FUS can interact with circTBC1D14, which can bind to the downstream flanking sequence of circTBC1D14 to induce cyclization. FUS is an essential biomarker associated with stress granules (SGs), and the authors find that hypoxic conditions can induce FUS\u2013circTBC1D14\u2010associated SG formation in the cytoplasm after modification by protein PRMT1. Subsequently, circTBC1D14 increases the stability of PRMT1 by inhibiting its K48\u2010regulated polyubiquitination, leading to the upregulation of PRMT1 expression. In addition, FUS\u2013circTBC1D14 SGs can initiate a cascade of SG\u2010linked proteins to recognize and control the elimination of SGs by recruiting LAMP1 and enhancing lysosome\u2010associated autophagy flux, thus contributing to the maintenance of cellular homeostasis and promoting tumor progression in TNBC. Overall, these findings reveal that circTBC1D14 is a potential prognostic indicator that can serve as a therapeutic target for TNBC treatment.<\/jats:p>","DOI":"10.1002\/advs.202204988","type":"journal-article","created":{"date-parts":[[2023,2,19]],"date-time":"2023-02-19T22:21:07Z","timestamp":1676845267000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Hypoxia\u2010Induced FUS\u2013circTBC1D14 Stress Granules Promote Autophagy in TNBC"],"prefix":"10.1002","volume":"10","author":[{"given":"Ying","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Breast Surgery General Surgery Qilu Hospital of Shandong University  Ji'nan Shandong 250012 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery General Surgery Qilu Hospital of Shandong University  Ji'nan Shandong 250012 P. R. 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