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Vascular cast is designed to wrap the vein\u2010artery grafts, thereby adjusting the diameter and property mismatches by relying on the elastic fixity. Here, a small bridge connection in the cast structure serves as an essential element to prevent stress concentrations due to the improved elastic fixity. Consequently, the vein dilation is efficiently suppressed, healthy (laminar and helical) flow is induced effectively, and the heathy functions of vein grafting are promoted, as indicated by the flow directional alignment of endothelial cells with arterialization, muscle expansion, and improved contractility. Finally, collaborative effects of the bridge drastically suppress stenosis with patency improvement. As a key technical point, the advantages of the bridge addition are validated via the computational modeling of fluid\u2013structure interaction, followed by a customized ex vivo set\u2010up and analyses. The calculated effects are verified using a series of cell, rat, and canine models towards translation. The bridge acted like \u201cLittle Dutch boy\u201d who saved the big mass using one finger by supporting the cast function.<\/jats:p>","DOI":"10.1002\/advs.202204993","type":"journal-article","created":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T09:53:15Z","timestamp":1675331595000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Vascular Cast to Program Antistenotic Hemodynamics and Remodeling of Vein Graft"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6383-2136","authenticated-orcid":false,"given":"Hyunsu","family":"Ha","sequence":"first","affiliation":[{"name":"Department of Medical Engineering Yonsei University College of Medicine  50\u20131 Yonsei\u2010ro Seodaemun\u2010gu Seoul 03722 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ju Young","family":"Park","sequence":"additional","affiliation":[{"name":"TMD LAB Co. 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