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A 3D bioprinted biomimetic periodontal module is designed with high architectural integrity using a methacrylate gelatin\/decellularized extracellular matrix (GelMA\/dECM) cell\u2010laden bioink. The module presents favorable mechanical properties and orientation guidance by high\u2010precision topographical cues and provides a biochemical environment conducive to regulating encapsulated cell behavior. The dECM features robust immunomodulatory activity, reducing the release of proinflammatory factors by M1 macrophages and decreasing local inflammation in Sprague Dawley rats. In a clinically relevant critical\u2010size periodontal defect model, the bioprinted module significantly enhances the regeneration of hybrid periodontal tissues in beagles, especially the anchoring structures of the bone\u2013ligament interface, well\u2010aligned periodontal fibers, and highly mineralized alveolar bone. 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