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In this study, polypyrrole (Ppy) nanoparticles enveloping a 3D frame of sulfonated polyether ether ketone (SP) surface are constructed, which enhance the surface modulus and hardness of the sulfonated layer by forming a cooperative structure of simulated reinforced concrete and exhibit a superior photothermal effect. Ppy\u2010coated SP could quickly accumulate heat on the surface by responding to 808\u00a0nm near\u2010infrared (NIR) light, thereby killing bacteria, and destroying biofilms. Under NIR stimulation, the phagocytosis and M1 activation of macrophages cultured on Ppy\u2010coated SP are enhanced by activating complement 3 and its receptor, CD11b. Phagocytosis and M1 activation are impaired along with abolishment of NIR stimulation in the Ppy\u2010coated SP group, which is favorable for tissue repair. Ppy\u2010coated SP promotes Collagen\u2010I, vascular endothelial growth factor, connective tissue growth factor, and\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010actin (Acta2) expression by inducing M2 polarization owing to its higher surface modulus. Overall, Ppy\u2010coated SP with enhanced mechanical properties could be a good candidate for clinical percutaneous implants through on\u2010off phagocytosis and switchable macrophage activation stimulated with NIR.\n                  <\/jats:p>","DOI":"10.1002\/advs.202205048","type":"journal-article","created":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T06:49:54Z","timestamp":1671000594000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["On\u2010Off Phagocytosis and Switchable Macrophage Activation Stimulated with NIR for Infected Percutaneous Tissue Repair of Polypyrrole\u2010Coated Sulfonated PEEK"],"prefix":"10.1002","volume":"10","author":[{"given":"Xingdan","family":"Liu","sequence":"first","affiliation":[{"name":"State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences  Shanghai 200050 China"},{"name":"Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences  Beijing 100049 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haifeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences  Shanghai 200050 China"},{"name":"Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences  Beijing 100049 China"},{"name":"School of Chemistry and Materials Science Hangzhou Institute for Advanced Study University of Chinese Academy of Sciences  1 Sub\u2010lane Xiangshan Hangzhou 310024 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bangcheng","family":"Yan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences  Shanghai 200050 China"},{"name":"Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences  Beijing 100049 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelvin W. 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