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In the present study, it is found that high housing density remarkably increases the stress hormone (corticosterone), accelerates aging\u2010related processes as indicated by telomere length (in brain and liver cells) and DNA damage or inflammation (as revealed by tumor necrosis factor\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    and interleukin\u201010\u00a0levels), and reduces the lifespan of Brandt's vole (\n                    <jats:italic>Lasiopodomys brandtii<\/jats:italic>\n                    ). Fecal microbiota transplantation from donor voles of habitats with different housing densities induces similar changes in aging\u2010related processes in recipient voles. The elimination of high housing density or butyric acid administration delays the appearance of aging\u2010related markers in the brain and liver cells of voles housed at high\u2010density. This study suggests that gut microorganisms may play a significant role in regulating the density\u2010dependent aging\u2010related processes and subsequent population dynamics of animals, and can be used as potential targets for alleviating stress\u2010related aging in humans exposed to high\u2010density crowding stress.\n                  <\/jats:p>","DOI":"10.1002\/advs.202205346","type":"journal-article","created":{"date-parts":[[2023,3,25]],"date-time":"2023-03-25T15:55:27Z","timestamp":1679759727000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Gut Microbiota is Associated with Aging\u2010Related Processes of a Small Mammal Species under High\u2010Density Crowding Stress"],"prefix":"10.1002","volume":"10","author":[{"given":"Xiaoming","family":"Xu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Integrated Management of Pest Insects and Rodents Institute of Zoology Chinese Academy of 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