{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:24:03Z","timestamp":1786976643798,"version":"build-2736575974"},"reference-count":57,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T00:00:00Z","timestamp":1668643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32102642"],"award-info":[{"award-number":["32102642"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31872487"],"award-info":[{"award-number":["31872487"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Rabies is a fatal neurological zoonotic disease caused by the rabies virus (RABV), and the approved post\u2010exposure prophylaxis (PEP) procedure remains unavailable in areas with inadequate medical systems. Although strategies have been proposed for PEP and postinfection treatment (PIT), because of the complexity of the treatment procedures and the limited curative outcome, developing an effective treatment strategy remains a holy grail in rabies research. Herein, a facile approach is proposed involving photothermal therapy (PTT) and photothermally triggered immunological effects to realize effective PEP and PIT simultaneously. The designed photothermal agent (N\n                    <jats:sup>+<\/jats:sup>\n                    TT\u2010\n                    <jats:italic>m<\/jats:italic>\n                    CB nanoparticles) featured positively charged functional groups and high photo\u2010to\u2010heat efficiency, which are favorable for virus targeting and inactivation. The level of the virus at the site of infection in mice is significantly decreased upon treatment with orthotopic PTT, and the transfer of the virus to the brain is significantly inhibited. Furthermore, the survival ratio of the mice three days postinfection is increased by intracranial injection of N\n                    <jats:sup>+<\/jats:sup>\n                    TT\u2010\n                    <jats:italic>m<\/jats:italic>\n                    CB and laser irradiation. Overall, this work provides a platform for the effective treatment of RABV and opens a new avenue for future antiviral studies.\n                  <\/jats:p>","DOI":"10.1002\/advs.202205461","type":"journal-article","created":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T04:43:19Z","timestamp":1668660199000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Treat the \u201cUntreatable\u201d by a Photothermal Agent: Triggering Heat and Immunological Responses for Rabies Virus Inactivation"],"prefix":"10.1002","volume":"10","author":[{"given":"Yujie","family":"Bai","sequence":"first","affiliation":[{"name":"Key Laboratory of Zoonosis Research Ministry of Education College of Veterinary Medicine Jilin University  Changchun 130062 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei","family":"Huang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Zoonosis Research Ministry of Education College of Veterinary Medicine Jilin University  Changchun 130062 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Feng","sequence":"additional","affiliation":[{"name":"Changchun Veterinary Research Institute Chinese Academy of Agricultural Sciences  Changchun 130122 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Zoonosis Research Ministry of Education College of Veterinary Medicine Jilin University  Changchun 130062 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingbo","family":"Huang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Zoonosis Research Ministry of Education College of Veterinary Medicine Jilin University  Changchun 130062 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongli","family":"Jin","sequence":"additional","affiliation":[{"name":"Key Laboratory of Zoonosis Research Ministry of Education College of Veterinary Medicine Jilin University  Changchun 130062 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Zoonosis Research Ministry of Education College of Veterinary Medicine Jilin University  Changchun 130062 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingxuan","family":"Sun","sequence":"additional","affiliation":[{"name":"Key Laboratory of Zoonosis Research Ministry of Education College of Veterinary Medicine Jilin University  Changchun 130062 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Li","sequence":"additional","affiliation":[{"name":"Changchun Veterinary Research Institute Chinese Academy of Agricultural Sciences  Changchun 130122 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haili","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Zoonosis Research Ministry of Education College of Veterinary Medicine Jilin University  Changchun 130062 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianzhu","family":"Xia","sequence":"additional","affiliation":[{"name":"Changchun Veterinary Research Institute Chinese Academy of Agricultural Sciences  Changchun 130122 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0293-964X","authenticated-orcid":false,"given":"Ben Zhong","family":"Tang","sequence":"additional","affiliation":[{"name":"School of Science and Engineering Shenzhen Institute of Aggregate Science and Technology The Chinese University of Hong Kong  Shenzhen Guangdong 518172 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hualei","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Zoonosis Research Ministry of Education College of Veterinary Medicine Jilin University  Changchun 130062 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,17]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2018.11"},{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-015-1511-3"},{"key":"e_1_2_8_1_3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007189"},{"key":"e_1_2_8_1_4","unstructured":"d)W.H.O. https:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/rabies(accessed: May 2021)."},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.20506\/rst.37.2.2828"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2018.08.086"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0006951"},{"key":"e_1_2_8_4_1","doi-asserted-by":"crossref","first-page":"12628","DOI":"10.15252\/emmm.202012628","volume":"12","author":"Melo G. 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