{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:02:15Z","timestamp":1790665335520,"version":"4.1.0"},"reference-count":74,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T00:00:00Z","timestamp":1680134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273454"],"award-info":[{"award-number":["82273454"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172834"],"award-info":[{"award-number":["82172834"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81972651"],"award-info":[{"award-number":["81972651"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172698"],"award-info":[{"award-number":["82172698"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2017A030312009"],"award-info":[{"award-number":["2017A030312009"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>High\u2010grade meningioma has an unsatisfactory outcome despite surgery and postoperative radiotherapy; however, the factors driving its malignancy and recurrence remain largely unknown, which limits the development of systemic treatments. Single\u2010cell RNA sequencing (scRNA\u2010Seq) technology is a powerful tool for studying intratumoral cellular heterogeneity and revealing the roles of various cell types in oncogenesis. In this study, scRNA\u2010Seq is used to identify a unique initiating cell subpopulation (SULT1E1<jats:sup>+<\/jats:sup>) in high\u2010grade meningiomas. This subpopulation modulates the polarization of M2\u2010type macrophages and promotes meningioma progression and recurrence. A novel patient\u2010derived meningioma organoid (MO) model is established to characterize this unique subpopulation. The resulting MOs fully retain the aggressiveness of SULT1E1<jats:sup>+<\/jats:sup> and exhibit invasiveness in the brain after orthotopic transplantation. By targeting SULT1E1<jats:sup>+<\/jats:sup> in MOs, the synthetic compound SRT1720 is identified as a potential agent for systemic treatment and radiation sensitization. These findings shed light on the mechanism underlying the malignancy of high\u2010grade meningiomas and provide a novel therapeutic target for refractory high\u2010grade meningioma.<\/jats:p>","DOI":"10.1002\/advs.202205525","type":"journal-article","created":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T09:25:30Z","timestamp":1680168330000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Novel Human Meningioma Organoids Recapitulate the Aggressiveness of the Initiating Cell Subpopulations Identified by ScRNA\u2010Seq"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2575-9403","authenticated-orcid":false,"given":"Meng","family":"Huang","sequence":"first","affiliation":[{"name":"Key Laboratory of Stem Cells and Tissue Engineering Sun Yat\u2010Sen University Ministry of Education  510080 Guangzhou China"},{"name":"Medical Research Institute Guangdong Provincial People's Hospital Guangdong Academy of Medical Sciences Southern Medical University  510080 Guangzhou China"},{"name":"Guangdong Cardiovascular Institute Guangdong Provincial People's Hospital Guangdong Academy of Medical Sciences  510080 Guangzhou China"},{"name":"Department of Neurosurgery in Xiangya Hospital Central South University  410008 Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao","family":"Xu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Stem Cells and Tissue Engineering Sun Yat\u2010Sen University Ministry of Education  510080 Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzhe","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery in Xiangya Hospital Central South University  410008 Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Shang","sequence":"additional","affiliation":[{"name":"Department of Pathology in Xiangya Hospital Central South University  Changsha 410008 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiudan","family":"Zhan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Stem Cells and Tissue Engineering Sun Yat\u2010Sen University Ministry of Education  510080 Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoyin","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery in Xiangya Hospital Central South University  410008 Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Hunan Children's Hospital  Changsha 410007 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery in Xiangya Hospital Central South University  410008 Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"He","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery in Xiangya Hospital Central South University  410008 Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Qin","sequence":"additional","affiliation":[{"name":"Key Laboratory of Stem Cells and Tissue Engineering Sun Yat\u2010Sen University Ministry of Education  510080 Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0774-2571","authenticated-orcid":false,"given":"Wei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Stem Cells and Tissue Engineering Sun Yat\u2010Sen University Ministry of Education  510080 Guangzhou China"},{"name":"Medical Research Institute Guangdong Provincial People's Hospital Guangdong Academy of Medical Sciences Southern Medical University  510080 Guangzhou China"},{"name":"Guangdong Cardiovascular Institute Guangdong Provincial People's Hospital Guangdong Academy of Medical Sciences  510080 Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyong","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery in Xiangya Hospital Central South University  410008 Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery in Xiangya Hospital Central South University  410008 Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,30]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noaa200"},{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.579599"},{"key":"e_1_2_10_1_3","doi-asserted-by":"publisher","DOI":"10.3171\/2014.7.JNS131644"},{"key":"e_1_2_10_1_4","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/63.4.275"},{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30321-7"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/14737175.2018.1429920"},{"key":"e_1_2_10_2_3","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(06)70625-1"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-010-0342-2"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-009-9934-0"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCO.0000000000000687"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noy178"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-020-02188-w"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djv377"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01233-9"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.01.018"},{"key":"e_1_2_10_7_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.03.009"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-18582-7"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.2178"},{"key":"e_1_2_10_8_3","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-022-02455-y"},{"key":"e_1_2_10_8_4","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2022.103173"},{"key":"e_1_2_10_8_5","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-022-01113-8"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14049"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-020-01528-0"},{"key":"e_1_2_10_9_3","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3818"},{"key":"e_1_2_10_9_4","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15081"},{"key":"e_1_2_10_9_5","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20059-6"},{"key":"e_1_2_10_10_1","volume":"1","author":"Proctor D. T.","year":"2019","journal-title":"Neurooncol Adv"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-022-01051-9"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2019.04.005"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-018-0007-6"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2008.08.017"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-018-0679-9"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm200903z"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noab106"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-020-02247-2"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-013-1093-x"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noz061"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-18-3962"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-022-01061-8"},{"key":"e_1_2_10_22_1","volume":"2022","author":"Fu X. H.","year":"2022","journal-title":"J Immunol Res"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.583084"},{"key":"e_1_2_10_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2011.01.005"},{"key":"e_1_2_10_23_3","doi-asserted-by":"publisher","DOI":"10.1007\/s10143-021-01642-x"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-022-03979-9"},{"key":"e_1_2_10_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noab075"},{"key":"e_1_2_10_24_3","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noy136"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10030484"},{"key":"e_1_2_10_25_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-017-0600-4"},{"key":"e_1_2_10_25_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2021.07.009"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13071633"},{"key":"e_1_2_10_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2007.09.004"},{"key":"e_1_2_10_26_3","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-022-02954-9"},{"key":"e_1_2_10_26_4","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21207697"},{"key":"e_1_2_10_26_5","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2017.4129"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(17)30155-9"},{"key":"e_1_2_10_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03850-3"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noab213"},{"key":"e_1_2_10_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noaa226"},{"key":"e_1_2_10_28_3","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.00784"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3337"},{"key":"e_1_2_10_29_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.155300"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathophysiology28010004"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-020-0402-9"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2021.10.035"},{"key":"e_1_2_10_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noab155"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-59038-3_3"},{"key":"e_1_2_10_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2015.07.019"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nox071"},{"key":"e_1_2_10_34_2","doi-asserted-by":"publisher","DOI":"10.1093\/neuros\/nyaa348"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.13048"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2017.168"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2022.156776"},{"key":"e_1_2_10_37_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1419119111"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-021-01999-9"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202205525","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T09:25:57Z","timestamp":1759742757000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202205525"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,30]]},"references-count":74,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1002\/advs.202205525"],"URL":"https:\/\/doi.org\/10.1002\/advs.202205525","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,30]]},"assertion":[{"value":"2022-09-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2205525"}}