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A previous study proved that optogenetic modulation could precisely inhibit cardiac sympathetic hyperactivity and prevent acute ischemia\u2010induced VAs. Here, a wireless self\u2010powered optogenetic modulation system is introduced, which achieves long\u2010term precise cardiac neuromodulation in ambulatory canines. The wireless self\u2010powered optical system based on a triboelectric nanogenerator is powered by energy harvested from body motion and realized the effective optical illumination that is required for optogenetic neuromodulation (ON). It is further demonstrated that long\u2010term ON significantly mitigates MI\u2010induced sympathetic remodeling and hyperactivity, and improves a variety of clinically relevant outcomes such as improves ventricular dysfunction, reduces infarct size, increases electrophysiological stability, and reduces susceptibility to VAs. These novel insights suggest that wireless ON holds translational potential for the clinical treatment of arrhythmia and other cardiovascular diseases related to sympathetic hyperactivity. Moreover, this innovative self\u2010powered optical system may provide an opportunity to develop implantable\/wearable and self\u2010controllable devices for long\u2010term optogenetic therapy.<\/jats:p>","DOI":"10.1002\/advs.202205551","type":"journal-article","created":{"date-parts":[[2023,1,26]],"date-time":"2023-01-26T00:49:16Z","timestamp":1674694156000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Wireless Self\u2010Powered Optogenetic System for Long\u2010Term Cardiac Neuromodulation to Improve Post\u2010MI Cardiac Remodeling and Malignant Arrhythmia"],"prefix":"10.1002","volume":"10","author":[{"given":"Liping","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Cardiology Renmin Hospital of Wuhan University Hubei Key Laboratory of Autonomic Nervous System Modulation Cardiac Autonomic Nervous System Research Center of Wuhan University Taikang Center for Life and Medical Sciences Wuhan University Cardiovascular Research Institute Wuhan University Hubei Key Laboratory of Cardiology  Wuhan 430060 P. 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