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Although great advances in the fields of biotechnology, microfluidics, and nanotechnologies have been made in recent years, this astonishing recognition system can hardly be replaced by any artificial sensors designed so far. Here, taste organoids are coupled with an extracellular potential sensor array to form a novel bioelectronic organoid and developed a taste organoids\u2010on\u2010a\u2010chip system (TOS) for highly mimicking the biological sense of taste ex vivo with high stability and repeatability. The taste organoids maintain key taste receptors expression after the third passage and high cell viability during 7 days of on\u2010chip culture. Most importantly, the TOS not only distinguishs sour, sweet, bitter, and salt stimuli with great specificity, but also recognizes varying concentrations of the stimuli through an analytical method based on the extraction of signal features and principal component analysis. It is hoped that this bioelectronic tongue can facilitate studies in food quality controls, disease modelling, and drug screening.<\/jats:p>","DOI":"10.1002\/advs.202206101","type":"journal-article","created":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T15:30:38Z","timestamp":1673623838000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Mimicking the Biological Sense of Taste In Vitro Using a Taste Organoids\u2010on\u2010a\u2010Chip System"],"prefix":"10.1002","volume":"10","author":[{"given":"Jianguo","family":"Wu","sequence":"first","affiliation":[{"name":"Biosensor National Special Laboratory Key Laboratory for Biomedical Engineering of Education Ministry Department of Biomedical Engineering Zhejiang University  Hangzhou 310027 P. R. China"},{"name":"The MOE Frontier Science Center for Brain Science and Brain\u2010Machine Integration Zhejiang University  Hangzhou 310027 P. R. 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