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Magnetic resonance imaging (MRI) is emerging as a powerful tool for the detection of cardiac abnormalities, but the sensitive and direct ROS\u2010response MRI probe remains to be developed. This restricts the early diagnosis of DCM and prevents timely clinical interventions, resulting in serious and irreversible pathophysiological abnormalities. Herein, a novel ROS\u2010response contrast\u2010enhanced MRI nanoprobe (RCMN) is developed by multi\u2010functionalizing fluorinated carbon nanosheets (FCNs) with multi\u2010hydroxyl and 2,2,6,6\u2010tetramethylpiperidin\u20101\u2010oxyl groups. RCMNs capture ROS and then gather in the heart provisionally, which triggers MRI signal changes to realize the in vivo detection of ROS. In contrast to the clinical MRI agents, the cardiac abnormalities of disease mice is detected 8 weeks in advance with the assistance of RCMNs, which greatly advances the diagnostic window of DCM. To the best of the knowledge, this is the first ROS\u2010response metal\u2010free T\n                    <jats:sub>2<\/jats:sub>\n                    \u2010weighted MRI probe for the early diagnosis of DCM mice model. Furthermore, RCMNs can timely scavenge excessively produced ROS to alleviate oxidative stress.\n                  <\/jats:p>","DOI":"10.1002\/advs.202206171","type":"journal-article","created":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T21:08:20Z","timestamp":1672780100000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["A Multifunctional Integrated Metal\u2010Free MRI Agent for Early Diagnosis of Oxidative Stress in a Mouse Model of Diabetic Cardiomyopathy"],"prefix":"10.1002","volume":"10","author":[{"given":"Zhuang","family":"Nie","sequence":"first","affiliation":[{"name":"College of Polymer Science and Engineering State Key Laboratory of Polymer Material and Engineering Sichuan University  Chengdu 610065 P. R. 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingwen","family":"Zheng","sequence":"additional","affiliation":[{"name":"Time Medical Ltd., Hong Kong Science &amp; Technology Park  Hong Kong 999077 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qihong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Radiology Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education West China Second University Hospital Sichuan University  20# South Renmin Road Chengdu Sichuan 610041 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingkun","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Radiology Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education West China Second University Hospital Sichuan University  20# South Renmin Road Chengdu Sichuan 610041 P. R. 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