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To address the poor survival and function loss of directly injected stem cells, efforts in this area are focus on the generation of efficient cell delivery vehicles. Herein, a novel extracellular matrix (ECM)\u2010inspired injectable hydrogel for ADSCs encapsulation and RA treatment is proposed. The hydrogel with dendritic polylysine and polysaccharide components is formed through the reversible Schiff base crosslinking. It possesses self\u2010healing capability, superior mechanical properties, minimal toxicity, and immunomodulatory ability. When encapsulated with ADSCs, the hydrogel could recover chronic inflammation by directly reversing the dominant macrophage phenotype from M1 to M2 and inhibiting the migration of fibroblast\u2010like synoviocytes. Through a collagen\u2010induced arthritis rat model, the tremendous therapeutic outcomes of this ADSCs\u2010laden hydrogel, including inflammation attenuation, cartilage protection, and bone mineral density promotion are demonstrated. These results make the ECM\u2010inspired hydrogel laden with ADSCs an ideal candidate for treating RA and other autoimmune disorders.<\/jats:p>","DOI":"10.1002\/advs.202206253","type":"journal-article","created":{"date-parts":[[2023,1,23]],"date-time":"2023-01-23T00:01:44Z","timestamp":1674432104000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["ECM\u2010Inspired Hydrogels with ADSCs Encapsulation for Rheumatoid Arthritis Treatment"],"prefix":"10.1002","volume":"10","author":[{"given":"Haofang","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Immunology Institute of Translational Medicine The Affiliated Drum Tower Hospital of Nanjing University Medical School  321 Zhongshan Road Nanjing 210008 P. R. China"},{"name":"Department of Rheumatology and Immunology The First Affiliated Hospital of Anhui Medical University  218 Jixi Road Hefei 230022 P. R. 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