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Antibiotics fail to improve prognosis of patients with post\u2010stroke pneumonia, albeit suppressing infection, due to adverse impacts on the immune system. The current study reports that bone marrow mesenchymal stem cells (BM\u2010MSC) downregulate bacterial load in the lungs of stroke mice models. RNA\u2010sequencing of the lung from BM\u2010MSC\u2010treated stroke models indicates that BM\u2010MSC modulates pulmonary macrophage activities after cerebral ischemia. Mechanistically, BM\u2010MSC promotes the bacterial phagocytosis of pulmonary macrophages through releasing migrasomes, which are migration\u2010dependent extracellular vesicles. With liquid chromatography\u2010tandem mass spectrometry (LC\u2010MS\/MS), the result shows that BM\u2010MSC are found to load the antibacterial peptide dermcidin (DCD) in migrasomes upon bacterial stimulation. Besides the antibiotic effect, DCD enhances LC3\u2010associated phagocytosis (LAP) of macrophages, facilitating their bacterial clearance. The data demonstrate that BM\u2010MSC is a promising therapeutic candidate against post\u2010stroke pneumonia, with dual functions of anti\u2010infection and immunol modulation, which is more than a match for antibiotics treatment.<\/jats:p>","DOI":"10.1002\/advs.202206432","type":"journal-article","created":{"date-parts":[[2023,5,28]],"date-time":"2023-05-28T23:47:06Z","timestamp":1685317626000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["Bone Marrow Mesenchymal Stem Cell\u2010Derived Dermcidin\u2010Containing Migrasomes enhance LC3\u2010Associated Phagocytosis of Pulmonary Macrophages and Protect against Post\u2010Stroke Pneumonia"],"prefix":"10.1002","volume":"10","author":[{"given":"Tiemei","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neurology Mental and Neurological Disease Research Center the Third Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou 510630 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