{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T02:03:39Z","timestamp":1790215419979,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T00:00:00Z","timestamp":1681689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82102204"],"award-info":[{"award-number":["82102204"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2020M680478"],"award-info":[{"award-number":["2020M680478"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Patients with triple\u2010negative breast cancer (TNBC) have the worst clinical outcomes when compared to other subtypes of breast cancer. Nanotechnology\u2010assisted photothermal therapy (PTT) opens new opportunities for precise cancer treatment. However, thermoresistance caused by PTT, as well as uncertainty in the physiological metabolism of existing phototherapeutic nanoformulations, severely limit their clinical applications. Herein, based on the clinically chemotherapeutic drug mitoxantrone (MTO), a multifunctional nanoplatform (MTO\u2010micelles) is developed to realize mutually synergistic mild\u2010photothermal chemotherapy. MTO with excellent near\u2010infrared absorption (\u2248669\u00a0nm) can function not only as a chemotherapeutic agent but also as a photothermal transduction agent with elevated photothermal conversion efficacy (\n                    <jats:italic>\u019e<\/jats:italic>\n                    = 54.62%). MTO\u2010micelles can accumulate at the tumor site through the enhanced permeability and retention effect. Following local near\u2010infrared irradiation, mild hyperthermia (&lt;50\u00a0\u00b0C) assists MTO in binding tumor cell DNA, resulting in chemotherapeutic sensitization. In addition, downregulation of heat shock protein 70 (HSP70) expression due to enhanced DNA damage can in turn weaken tumor thermoresistance, boosting the efficacy of mild PTT. Both in vitro and in vivo studies indicate that MTO\u2010micelles possess excellent synergetic tumor inhibition effects. Therefore, the mild\u2010photothermal chemotherapy strategy based on MTO\u2010micelles has a promising prospect in the clinical transformation of TNBC treatment.\n                  <\/jats:p>","DOI":"10.1002\/advs.202206707","type":"journal-article","created":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T04:54:16Z","timestamp":1681707256000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["DNA Damage Inducer Mitoxantrone Amplifies Synergistic Mild\u2010Photothermal Chemotherapy for TNBC via Decreasing Heat Shock Protein 70 Expression"],"prefix":"10.1002","volume":"10","author":[{"given":"Zuqin","family":"Chen","sequence":"first","affiliation":[{"name":"Medical School of Chinese PLA  No. 28 Fuxing Road Beijing 100853 P. R. China"},{"name":"Department of Radiology The First Medical Center Chinese PLA General Hospital  Beijing 100853 P. R. 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