{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T11:57:11Z","timestamp":1791633431804,"version":"4.3.4"},"reference-count":39,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T00:00:00Z","timestamp":1681084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82072049"],"award-info":[{"award-number":["82072049"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Acetaminophen (APAP) overdose is a leading cause of drug\u2010induced liver injury and acute liver failure, while the detection, prognosis prediction, and therapy for APAP\u2010induced liver injury (AILI) remain improved. Here, it is determined that the temporal pattern of circulating cell\u2010free DNA (cfDNA) is strongly associated with damage and inflammation parameters in AILI. CfDNA is comparable to alanine aminotransferase (ALT) in predicting mortality and outperformed ALT when combined with ALT in AILI. The depletion of cfDNA or neutrophils alleviates liver damage, while the addition of cfDNA or adoptive transfer of neutrophils exacerbates the damage. The combination of DNase I and\n                    <jats:italic>N<\/jats:italic>\n                    \u2010acetylcysteine attenuates AILI significantly. This study establishes that cfDNA is a mechanistic biomarker to predict mortality in AILI mice. The combination of scavenging cfDNA and reducing oxidative damage provides a promising treatment for AILI.\n                  <\/jats:p>","DOI":"10.1002\/advs.202206789","type":"journal-article","created":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T05:39:54Z","timestamp":1681105194000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Circulating Cell\u2010Free DNAs as a Biomarker and Therapeutic Target for Acetaminophen\u2010Induced Liver Injury"],"prefix":"10.1002","volume":"10","author":[{"given":"Madi","family":"Sun","sequence":"first","affiliation":[{"name":"School of Biomedical Sciences and Engineering South China University of Technology Guangzhou International Campus  Guangzhou Guangdong 510630 China"},{"name":"National Engineering Research Center for Tissue Restoration and Reconstruction South China University of Technology Guangzhou International Campus  Guangzhou Guangdong 510630 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