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A supramolecular photoactive G\u2010quartet based material is reported, which is self\u2010assembled from guanosine (G) and 4\u2010formylphenylboronic acid\/1,8\u2010diaminooctane, with incorporation of riboflavin as a photocatalyst to the G4 nanowire, for post\u2010irradiation photodynamic antibacterial therapy. The G4\u2010materials, which exhibit hydrogel\u2010like properties, provide a scaffold for loading riboflavin, and the reductant guanosine for the riboflavin for phototriggered production of the therapeutic H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    . The photocatalytic activity shows great tolerance against room temperature storage and heating\/cooling treatments. The riboflavin\u2010loaded G4 hydrogels, after photo\u2010irradiation, are capable of killing gram\u2010positive bacteria (e.g.,\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    ), gram\u2010negative bacteria (e.g.,\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    ), and multidrug resistant bacteria (methicillin\u2010resistant\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    ) with sterilization ratio over 99.999%. The post\u2010irradiated hydrogels also exhibit great antibacterial activity in the infected wound of the rats, revealing the potential of this novel concept in the light therapy.\n                  <\/jats:p>","DOI":"10.1002\/advs.202206851","type":"journal-article","created":{"date-parts":[[2023,1,29]],"date-time":"2023-01-29T08:31:37Z","timestamp":1674981097000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["A H\n                    <sub>2<\/sub>\n                    O\n                    <sub>2<\/sub>\n                    \u2010Supplied Supramolecular Material for Post\u2010irradiated Infected Wound Treatment"],"prefix":"10.1002","volume":"10","author":[{"given":"Peidong","family":"Du","sequence":"first","affiliation":[{"name":"State Key Laboratory of Organic\u2010Inorganic Composites Key Laboratory of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology, Ministry of Education) Beijing Laboratory of Biomedical Materials Beijing University of Chemical Technology  Beijing 100029 P. 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