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Here, a novel multi\u2010antiviral metastable iron sulfides (mFeS) against various influenza <jats:italic>A\/B<\/jats:italic> subtype viruses is developed. This work finds that mFeS induces high levels of lipid peroxidation and \u2022OH free radicals in the conservative viral envelope, which depends on Fe<jats:sup>2+<\/jats:sup>. This phenomenon, termed as a viral ferroptosis, results in the loss of viral infectibility and pathogenicity in vitro and in vivo, respectively. Furthermore, the decoction of mFeS (Dc(mFeS)) inhibits cellular ferroptosis\u2010dependent intracellular viral replication by correcting the virus\u2010induced reprogrammed sulfur metabolism, a conserved cellular metabolism. Notably, personal protective equipment (PPE) that is loaded with mFeS provides good antiviral protection. Aerosol administration of mFeS combined with the decoction (mFeS&amp;Dc) has a potential therapeutic effect against H1N1 lethal infection in mice. 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