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Osteochondral defects induced by OA are accompanied by an inflammatory arthrosis microenvironment with overproduced reactive oxygen species (ROS), resulting in the exacerbation of defects and difficulty regenerating osteochondral tissues. Therefore, it is urgently needed to develop osteochondral scaffolds that can not only promote the integrated regeneration of cartilage and subchondral bone, but also possess ROS\u2010scavenging ability to protect tissues from oxidative stress. Herein, zinc\u2010cobalt bimetallic organic framework (Zn\/Co\u2010MOF) functionalized bioceramic scaffolds are designed for repairing osteochondral defects under OA environment. By functionalizing Zn\/Co\u2010MOF on the 3D\u2010printed beta\u2010tricalcium phosphate (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010TCP) scaffolds, the Zn\/Co\u2010MOF functionalized \u03b2\u2010TCP (MOF\u2010TCP) scaffolds with broad\u2010spectrum ROS\u2010scavenging ability are successfully developed. Benefiting from its catalytic active sites and degradation products, Zn\/Co\u2010MOF endows the scaffolds with excellent antioxidative and anti\u2010inflammatory properties to protect cells from ROS invasion, as well as dual\u2010bioactivities of simultaneously inducing osteogenic and chondrogenic differentiation in vitro. Furthermore, in vivo results confirm that MOF\u2010TCP scaffolds accelerate the integrated regeneration of cartilage and subchondral bone in severe osteochondral defects. This study offers a promising strategy for treating defects induced by OA as well as other inflammatory diseases.\n                  <\/jats:p>","DOI":"10.1002\/advs.202206875","type":"journal-article","created":{"date-parts":[[2023,2,24]],"date-time":"2023-02-24T22:27:15Z","timestamp":1677277635000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":92,"title":["Metal\u2010Organic Framework Functionalized Bioceramic Scaffolds with Antioxidative Activity for Enhanced Osteochondral Regeneration"],"prefix":"10.1002","volume":"10","author":[{"given":"Chaoqin","family":"Shu","sequence":"first","affiliation":[{"name":"State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences  Shanghai 200050 P. R. 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