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The efficacy of standard antibiotic\u2010based triple therapy is declining due to drug resistance development. Herein, a pH\u2010responsive reactive oxygen species (ROS) nanogenerator (Fe\u2010HMME@DHA@MPN) composed of acid\u2010responsive metal polyphenol network (MPN) shell and mesoporous metal\u2010organic nanostructure core [Fe\u2010HMME (hematoporphyrin monomethyl ether, sonosensitizer)] loaded with dihydroartemisinin (DHA) is reported. These nanoparticles generate more ROS singlet oxygen than sonosensitizer HMME under ultrasonication, and this sonodynamic process is fueled by oxygen generated through Fenton\/Fenton\u2010like reactions of the degraded product in gastric acid Fe (II) and hydrogen peroxide (H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    ) in the infection microenvironment. The encapsulated DHA, as a hydroperoxide source, is found to enhance the peroxidase\u2010like activity of the Fe\u2010HMME@DHA@MPN to generate ROS hydroxyl radical, beneficial for the microenvironment without sufficient H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    . In vitro experiments demonstrate that the ROS nanogenerators are capable of killing multidrug\u2010resistant\n                    <jats:italic>H. pylori<\/jats:italic>\n                    and removing biofilm, and ROS nanogenerators show high therapeutic efficacy in a\n                    <jats:italic>H. pylori<\/jats:italic>\n                    infection mouse model. Unlike the triple therapy, the nanogenerators display negligible side effects toward the normal gut microbiota. Taken together, these self\u2010enhanced ROS nanogenerators have a great potential for treatment of\n                    <jats:italic>H. pylori<\/jats:italic>\n                    infection.\n                  <\/jats:p>","DOI":"10.1002\/advs.202206957","type":"journal-article","created":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T23:54:42Z","timestamp":1682985282000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Gastric Acid\u2010Responsive ROS Nanogenerators for Effective Treatment of\n                    <i>Helicobacter pylori<\/i>\n                    Infection without Disrupting Homeostasis of Intestinal Flora"],"prefix":"10.1002","volume":"10","author":[{"given":"Jiayin","family":"Yu","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Science (Shenzhen) Shenzhen Campus of Sun Yat\u2010sen University  Shenzhen 518107 P. R. 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