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Thus, the preparation of multifunctional materials with higher photothermal conversion efficiency and catalytic activity can achieve better synergistic therapeutic effects for melanoma. In this study, a Cu\u2013Zn bimetallic single\u2010atom (Cu\/PMCS) is constructed with augmented photothermal effect and catalytic activity due to the localized surface plasmon resonance (LSPR) effect. Density functional theory calculations confirmed that the enhanced photothermal effect of Cu\/PMCS is due to the appearance of a new d\u2010orbital transition with strong spin\u2010orbit coupling and the induced LSPR. Additionally, Cu\/PMCS exhibited increased catalytic activity in the Fenton\u2010like reaction and glutathione depletion capacity, further enhanced by increased temperature and LSPR. Consequently, Cu\/PMCS induced better synergistic anti\u2010melanoma effects via PTT\u2010CDT than PMCS in vitro and in vivo. Furthermore, compared with PMCS, Cu\/PMCS killed bacteria more quickly and effectively, thus facilitating wound healing owing to the enhanced photothermal effect and slow release of Cu<jats:sup>2+<\/jats:sup>. Cu\/PMCS promoted cell migration and angiogenesis and upregulated the expression of related genes to accelerate wound healing. Cu\/PMCS has potential applications in treating melanoma and repairing wounds with its antitumor, antibacterial, and wound\u2010healing properties.<\/jats:p>","DOI":"10.1002\/advs.202207342","type":"journal-article","created":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T07:58:50Z","timestamp":1682409530000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Copper\u2010Zinc Bimetallic Single\u2010Atom Catalysts with Localized Surface Plasmon Resonance\u2010Enhanced Photothermal Effect and Catalytic Activity for Melanoma Treatment and Wound\u2010Healing"],"prefix":"10.1002","volume":"10","author":[{"given":"Lidan","family":"Liu","sequence":"first","affiliation":[{"name":"State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences  Shanghai 200050 China"},{"name":"Center of Materials Science and Optoelectronics Engineering University 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