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Previous studies have demonstrated that the tumor microenvironment (TME) dominates immunotherapy; therefore, an effective TME classification strategy is required. In this study, five crucial immunophenotype\u2010related molecules (WARS, UBE2L6, GZMB, BATF2, and LAG\u20103) in the TME are determined in five public gastric cancer (GC) datasets (<jats:italic>n<\/jats:italic> = 1426) and an in\u2010house sequencing dataset (<jats:italic>n<\/jats:italic> = 79). Based on this, a GC immunophenotypic score (IPS) is constructed using the least absolute shrinkage and selection operator (LASSO) Cox, and randomSurvivalForest. IPS<jats:sup>Low<\/jats:sup> is characterized as immune\u2010activated, and IPS<jats:sup>High<\/jats:sup> is immune\u2010silenced. Data from seven centers (<jats:italic>n<\/jats:italic> = 1144) indicate that the IPS is a robust and independent biomarker for GC and superior to the AJCC stage. Furthermore, patients with an IPS<jats:sup>Low<\/jats:sup> and a combined positive score of \u22655 are likely to benefit from neoadjuvant anti\u2010PD\u20101 therapy. In summary, the IPS can be a useful quantitative tool for immunophenotyping to improve clinical outcomes and provide a practical reference for implementing neoadjuvant ICI therapy for patients with GC.<\/jats:p>","DOI":"10.1002\/advs.202207417","type":"journal-article","created":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T23:29:51Z","timestamp":1680218991000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Tumor Immunophenotyping\u2010Derived Signature Identifies Prognosis and Neoadjuvant Immunotherapeutic Responsiveness in Gastric Cancer"],"prefix":"10.1002","volume":"10","author":[{"given":"Jia\u2010Bin","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Gastric Surgery Department of General Surgery Fujian Medical University Union Hospital  Fuzhou 350001 P. R. 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