{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T14:16:38Z","timestamp":1785766598329,"version":"3.56.0"},"reference-count":35,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T00:00:00Z","timestamp":1681948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U22A20184"],"award-info":[{"award-number":["U22A20184"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61874049"],"award-info":[{"award-number":["61874049"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52250077"],"award-info":[{"award-number":["52250077"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52272080"],"award-info":[{"award-number":["52272080"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Intelligent wearable devices are essential for telemedicine healthcare as they enable real\u2010time monitoring of physiological information. Elaborately constructing synapse\u2010inspired materials provides a crucial guidance for designing high\u2010performance sensors toward multiplex stimuli response. However, a realistic mimesis both in the \u201cstructure and sense\u201d of biological synapses to obtain advanced multi\u2010functions is still challenging but essential for simplifying subsequent circuit and logic programs. Herein, an ionic artificial synapse integrated with Ti<jats:sub>3<\/jats:sub>CNT<jats:italic><jats:sub>x<\/jats:sub><\/jats:italic> nanosheets in situ grown with zeolitic imidazolate framework flowers (ZIF\u2010L@Ti<jats:sub>3<\/jats:sub>CNT<jats:italic><jats:sub>x<\/jats:sub><\/jats:italic> composite) is constructed to concurrently mimic the structure and working mechanism of the synapse. The flexible sensor of the bio\u2010inspired ZIF\u2010L@Ti<jats:sub>3<\/jats:sub>CNT<jats:italic><jats:sub>x<\/jats:sub><\/jats:italic> composite exhibits excellent dual\u2010mode dimethylamine (DMA) and strain\u2010sensitive response with non\u2010overlapping resistance variations. The specific ions conduction working principle triggered by DMA gas or strain with the assistance of humidity is confirmed by the density functional theory simulation. Last, an intelligent wearable system is self\u2010developed by integrating the dual\u2010mode sensor into flexible printed circuits. This device is successfully applied in pluralistic monitoring of abnormal physiological signals of Parkinson's sufferers, including real\u2010time and accurate assessment of simulated DMA expiration and kinematic tremor signals. This work provides a feasible routine to develop intelligent multifunctional devices for upsurging telemedicine diagnosis.<\/jats:p>","DOI":"10.1002\/advs.202207663","type":"journal-article","created":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T14:48:31Z","timestamp":1682002111000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["A Wearable Healthcare Platform Integrated with Biomimetical Ions Conducted Metal\u2013Organic Framework Composites for Gas and Strain Sensing in Non\u2010Overlapping Mode"],"prefix":"10.1002","volume":"10","author":[{"given":"Qingqing","family":"Zhou","sequence":"first","affiliation":[{"name":"State Key Laboratory of Integrated Optoelectronics College of Electronic Science and Engineering Jilin University  Changchun 130012 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixun","family":"Geng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Integrated Optoelectronics College of Electronic Science and Engineering Jilin University  Changchun 130012 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Integrated Optoelectronics College of Electronic Science and Engineering Jilin University  Changchun 130012 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Shen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Integrated Optoelectronics College of Electronic Science and Engineering Jilin University  Changchun 130012 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zitong","family":"Kan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Integrated Optoelectronics College of Electronic Science and Engineering Jilin University  Changchun 130012 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Qi","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Integrated Optoelectronics College of Electronic Science and Engineering Jilin University  Changchun 130012 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songtao","family":"Hu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Integrated Optoelectronics College of Electronic Science and Engineering Jilin University  Changchun 130012 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biao","family":"Dong","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Integrated Optoelectronics College of Electronic Science and Engineering Jilin University  Changchun 130012 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Bai","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Integrated Optoelectronics College of Electronic Science and Engineering Jilin University  Changchun 130012 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5831-430X","authenticated-orcid":false,"given":"Lin","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Integrated Optoelectronics College of Electronic Science and Engineering Jilin University  Changchun 130012 P. R. China"},{"name":"Key Laboratory of Bionic Engineering Ministry of Education College of Biological and Agricultural Engineering Jilin University  Changchun 130025 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3897-5789","authenticated-orcid":false,"given":"Hongwei","family":"Song","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Integrated Optoelectronics College of Electronic Science and Engineering Jilin University  Changchun 130012 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luquan","family":"Ren","sequence":"additional","affiliation":[{"name":"Key Laboratory of Bionic Engineering Ministry of Education College of Biological and Agricultural Engineering Jilin University  Changchun 130025 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,20]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202107511"},{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c07891"},{"key":"e_1_2_7_1_3","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-32745-8"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11306-016-1041-6"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abd7865"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202200481"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c08482"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aao0098"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.matt.2022.02.020"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21319-9"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-14214-x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c08328"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nanoen.2022.107486"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201710418"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202115559"},{"key":"e_1_2_7_9_3","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202201705"},{"key":"e_1_2_7_9_4","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c02529"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202116282"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201705155"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202203528"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.0c07847"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aba7977"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compositesb.2019.107603"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b11446"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201102306"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201807161"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1TA10773A"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceramint.2016.02.059"},{"key":"e_1_2_7_19_1","first-page":"2927","volume":"8","author":"Ji P.","year":"2020","journal-title":"J. Mater. Chem."},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abo5201"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b02986"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b18891"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41560-018-0309-7"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsenergylett.1c01656"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c04188"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202207663","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T17:29:28Z","timestamp":1759771768000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202207663"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,20]]},"references-count":35,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10.1002\/advs.202207663"],"URL":"https:\/\/doi.org\/10.1002\/advs.202207663","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,20]]},"assertion":[{"value":"2022-12-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2207663"}}