{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T14:57:49Z","timestamp":1772117869422,"version":"3.50.1"},"reference-count":53,"publisher":"Wiley","issue":"27","license":[{"start":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T00:00:00Z","timestamp":1690502400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>High\u2010content time\u2010lapse embryo imaging assessed by machine learning is revolutionizing the field of in vitro fertilization (IVF). However, the vast majority of IVF embryos are not transferred to the uterus, and these masses of embryos with unknown implantation outcomes are ignored in current efforts that aim to predict implantation. Here, whether, and to what extent the information encoded within \u201csibling\u201d embryos from the same IVF cohort contributes to the performance of machine learning\u2010based implantation prediction is explored. First, it is shown that the implantation outcome is correlated with attributes derived from the cohort siblings. Second, it is demonstrated that this unlabeled data boosts implantation prediction performance. Third, the cohort properties driving embryo prediction, especially those that rescued erroneous predictions, are characterized. The results suggest that predictive models for embryo implantation can benefit from the overlooked, widely available unlabeled data of sibling embryos by reducing the inherent noise of the individual transferred embryo.<\/jats:p>","DOI":"10.1002\/advs.202207711","type":"journal-article","created":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T23:41:16Z","timestamp":1690587676000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Using Unlabeled Information of Embryo Siblings from the Same Cohort Cycle to Enhance In Vitro Fertilization Implantation Prediction"],"prefix":"10.1002","volume":"10","author":[{"given":"Noam","family":"Tzukerman","sequence":"first","affiliation":[{"name":"Department of Software and Information Systems Engineering Ben\u2010Gurion University of the Negev  Beer\u2010Sheva 84105 Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oded","family":"Rotem","sequence":"additional","affiliation":[{"name":"Department of Software and Information Systems Engineering Ben\u2010Gurion University of the Negev  Beer\u2010Sheva 84105 Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maya Tsarfati","family":"Shapiro","sequence":"additional","affiliation":[{"name":"Research Division AIVF Ltd.  Tel Aviv 69271 Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ron","family":"Maor","sequence":"additional","affiliation":[{"name":"Research Division AIVF Ltd.  Tel Aviv 69271 Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos","family":"Meseguer","sequence":"additional","affiliation":[{"name":"IVI Foundation Instituto de Investigaci\u00f3n Sanitaria La Fe  Valencia 46026 Spain"},{"name":"Department of Reproductive Medicine IVIRMA  Valencia 46015 Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniella","family":"Gilboa","sequence":"additional","affiliation":[{"name":"Research Division AIVF Ltd.  Tel Aviv 69271 Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel S.","family":"Seidman","sequence":"additional","affiliation":[{"name":"Research Division AIVF Ltd.  Tel Aviv 69271 Israel"},{"name":"The Sackler Faculty of Medicine Tel\u2010Aviv University  Tel\u2010Aviv 69978 Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1477-5478","authenticated-orcid":false,"given":"Assaf","family":"Zaritsky","sequence":"additional","affiliation":[{"name":"Department of Software and Information Systems Engineering Ben\u2010Gurion University of the Negev  Beer\u2010Sheva 84105 Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,7,28]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.0020041"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature25973"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2045"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0500398102"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-021-02196-z"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1017\/S2040174417000368"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/der256"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001703-199906000-00013"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.15419\/bmrat.v5i12.510"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dex344"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874120701004010170"},{"key":"e_1_2_9_12_1","first-page":"205","volume":"22","author":"Adolfsson E.","year":"2018","journal-title":"JBRA Assist. 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