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In articular cartilage, stem cells are characterized by overlapping lineages and uneven effectiveness. Within the first 12 weeks after trauma, the articular inflammatory microenvironment (AIME) plays a decisive role in determining the fate of stem cells and cartilage. The development of fibrocartilage and osteophyte hyperplasia is an adverse outcome of chronic inflammation, which results from an imbalance in the AIME during the cartilage tissue repair process. In this review, the sources for the different types of stem cells and their fate are summarized. The main pathophysiological events that occur within the AIME as well as their protagonists are also discussed. Additionally, regulatory strategies that may guide the fate of stem cells within the AIME are proposed. Finally, strategies that provide insight into AIME pathophysiology are discussed and the design of new materials that match the post\u2010traumatic progress of AIME pathophysiology in a spatial and temporal manner is guided. Thus, by regulating an appropriately modified inflammatory microenvironment, efficient stem cell\u2010mediated tissue repair may be achieved.<\/jats:p>","DOI":"10.1002\/advs.202207715","type":"journal-article","created":{"date-parts":[[2023,7,30]],"date-time":"2023-07-30T22:25:53Z","timestamp":1690755953000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Arthritic Microenvironment\u2010Dictated Fate Decisions for Stem Cells in Cartilage Repair"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3366-3690","authenticated-orcid":false,"given":"Songlin","family":"He","sequence":"first","affiliation":[{"name":"School of Medicine Nankai University  Tianjin 300071 China"},{"name":"Institute of Orthopedics the First Medical Center Chinese PLA General Hospital Beijing Key Lab of Regenerative Medicine in Orthopedics Key Laboratory of Musculoskeletal Trauma &amp; War Injuries PLA  Beijing 100853 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haotian","family":"Deng","sequence":"additional","affiliation":[{"name":"School of Medicine Nankai University  Tianjin 300071 China"},{"name":"Institute of Orthopedics the First Medical Center Chinese PLA General Hospital Beijing Key Lab of Regenerative Medicine in Orthopedics Key Laboratory of Musculoskeletal Trauma &amp; War Injuries PLA  Beijing 100853 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiqi","family":"Li","sequence":"additional","affiliation":[{"name":"School of Medicine Nankai University  Tianjin 300071 China"},{"name":"Institute of Orthopedics the First Medical Center Chinese PLA General Hospital Beijing Key Lab of Regenerative Medicine in Orthopedics Key Laboratory of Musculoskeletal Trauma &amp; War Injuries PLA  Beijing 100853 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Institute of Geriatrics Chinese PLA General Hospital  Beijing 100853 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongkang","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Orthopedics the First Medical Center Chinese PLA General Hospital Beijing Key Lab of Regenerative Medicine in Orthopedics Key Laboratory of Musculoskeletal Trauma &amp; War Injuries PLA  Beijing 100853 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziheng","family":"Xu","sequence":"additional","affiliation":[{"name":"Institute of Orthopedics the First Medical Center Chinese PLA General Hospital Beijing Key Lab of Regenerative Medicine in Orthopedics Key Laboratory of Musculoskeletal Trauma &amp; War Injuries PLA  Beijing 100853 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyun","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Medicine Nankai University  Tianjin 300071 China"},{"name":"Institute of Orthopedics the First Medical Center Chinese PLA General Hospital Beijing Key Lab of Regenerative Medicine in Orthopedics Key Laboratory of Musculoskeletal Trauma &amp; War Injuries PLA  Beijing 100853 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weimin","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Guangdong Provincial Key Laboratory of Orthopedics and Traumatology First Affiliated Hospital Sun Yat\u2010Sen University  Guangzhou Guangdong 510080 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7154-2227","authenticated-orcid":false,"given":"Quanyi","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Medicine Nankai University  Tianjin 300071 China"},{"name":"Institute of Orthopedics the First Medical Center Chinese PLA General Hospital Beijing Key Lab of Regenerative Medicine in Orthopedics Key Laboratory of Musculoskeletal Trauma &amp; War Injuries PLA  Beijing 100853 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,30]]},"reference":[{"key":"e_1_2_9_1_1","first-page":"1795","volume":"42","author":"Flanigan D. 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