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Thus, developing alternative antifungals that prevent drug resistance and induce immunity to eliminate <jats:italic>Candida<\/jats:italic> biofilms is crucial. Herein, a novel membrane\u2010targeted aggregation\u2010induced emission (AIE) photosensitizer (PS), TBTCP\u2010QY, is developed for highly efficient photodynamic therapy (PDT) of candidiasis. TBTCP\u2010QY has a high molar absorption coefficient and an excellent ability to generate <jats:sup>1<\/jats:sup>O<jats:sub>2<\/jats:sub> and \u2022OH, entering the interior of biofilms due to its high permeability. Furthermore, TBTCP\u2010QY can efficiently inhibit biofilm formation by suppressing the expression of genes related to the adhesion (<jats:italic>ALS3<\/jats:italic>, <jats:italic>EAP1<\/jats:italic>, and <jats:italic>HWP1<\/jats:italic>), invasion (<jats:italic>SAP1<\/jats:italic> and <jats:italic>SAP2<\/jats:italic>), and drug resistance (<jats:italic>MDR1<\/jats:italic>) of <jats:italic>C. albicans<\/jats:italic>, which is also advantageous for eliminating potential fungal resistance to treat clinical infectious diseases. TBTCP\u2010QY\u2010mediated PDT efficiently targets OC and VVC in vivo in a mouse model, induces immune response, relieves inflammation, and accelerates the healing of mucosal defects to combat infections caused by clinically isolated fluconazole\u2010resistant strains. Moreover, TBTCP\u2010QY demonstrates excellent biocompatibility, suggesting its potential applications in the clinical treatment of OC and VVC.<\/jats:p>","DOI":"10.1002\/advs.202207736","type":"journal-article","created":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T22:04:56Z","timestamp":1698185096000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["A Membrane\u2010Targeted Photosensitizer Prevents Drug Resistance and Induces Immune Response in Treating Candidiasis"],"prefix":"10.1002","volume":"10","author":[{"given":"Ming\u2010Yu","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Ministry of Education Key Laboratory of Combinatorial Biosynthesis and Drug Discovery TaiKang Center for Life and Medical Sciences Zhongnan Hospital of Wuhan University School of Pharmaceutical Sciences Wuhan University  Wuhan 430071 China"},{"name":"Sichuan Engineering Research Center for 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