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Surface states of materials affect the generation of free charges under the excitation source with energy less than the band gap, consequently influencing the MV dynamic effects. Herein, an MV responsive system with interface confined 2D metal\u2013organic framework (2D MOF) on oxidized carbon nanotube (CNT) is prepared, in which the ultrasmall Cu\u2010based 2D MOF possesses sufficient surface\/interface defects, endowing the system a large number of surface states. Under MV irradiation, the synthesized CNT\u20102D MOF not only efficiently absorbs and converts the microwave into heat for microwaveocaloric therapy (MCT) via enhanced hetero\u2010interfacial polarization, but also generates excited electrons via surface state for microwave dynamic therapy (MDT). This biocompatible CNT\u20102D MOF exhibits highly effective broad\u2010spectrum antimicrobial activity against seven pathogenic bacteria, including Gram\u2010negative and Gram\u2010positive pathogens, under 7\u00a0min MV irradiation. And this system is proven to efficiently eradicate <jats:italic>Staphylococcus aureus<\/jats:italic> infected rabbit tibia osteomyelitis. Significantly, MV\u2010excited MCT and MDT of CNT\u2010CuHHTP developed in this study makes a major step forward in antibiotic\u2010free MV therapy in deep tissue bacterial infection diseases.<\/jats:p>","DOI":"10.1002\/advs.202300084","type":"journal-article","created":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T02:18:46Z","timestamp":1684462726000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Enhancing Microwave Dynamic Effects via Surface States of Ultrasmall 2D MOF Triggered by Interface Confinement for Antibiotics\u2010Free Therapy"],"prefix":"10.1002","volume":"10","author":[{"given":"Yuqian","family":"Qiao","sequence":"first","affiliation":[{"name":"School of Materials Science and Engineering Peking University  Beijing 100871 P. R. 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