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Here the authors show that sevoflurane activates a cluster of urocortin 1 (UCN1\n                    <jats:sup>+<\/jats:sup>\n                    )\/cocaine\u2010 and amphetamine\u2010regulated transcript (CART\n                    <jats:sup>+<\/jats:sup>\n                    ) neurons in the midbrain involved in its anesthesia. Furthermore, growth hormone secretagogue receptor (GHSR) is highly enriched in sevoflurane\u2010activated UCN1\n                    <jats:sup>+<\/jats:sup>\n                    \/CART\n                    <jats:sup>+<\/jats:sup>\n                    cells and is necessary for sleep induction. Blockade of GHSR abolishes the excitatory effect of sevoflurane on UCN1\n                    <jats:sup>+<\/jats:sup>\n                    \/CART\n                    <jats:sup>+<\/jats:sup>\n                    neurons and attenuates its anesthetic effect. Collectively, their data suggest that anesthetic action of sevoflurane necessitates the GHSR activation in midbrain UCN1\n                    <jats:sup>+<\/jats:sup>\n                    \/CART\n                    <jats:sup>+<\/jats:sup>\n                    neurons, which provides a novel target including the nucleus and receptor in the field of anesthesia.\n                  <\/jats:p>","DOI":"10.1002\/advs.202300189","type":"journal-article","created":{"date-parts":[[2023,3,24]],"date-time":"2023-03-24T08:25:35Z","timestamp":1679646335000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["A Sleep\u2010Specific Midbrain Target for Sevoflurane Anesthesia"],"prefix":"10.1002","volume":"10","author":[{"given":"Tingting","family":"Yi","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Second Affiliated Hospital Third Military Medical University  Chongqing 400037 China"},{"name":"Department of 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