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Herein, a new system, which can escape immune recognition, has HIV\u20101 neutralizing capacity, and the ability to deliver siRNA specifically into HIV\u20101\u2010infected cells, is constructed by functionalizing siRNA delivery lipid nanoparticles with the lymphocyte membrane and 12p1. The constructed system is shown to escape uptake by the mononuclear phagocyte system. The constructed system exhibits strong binding ability with gp120, thus displaying distinguished neutralizing breadth and potency. The constructed system neutralizes all tested HIV\u20101 pseudotyped viruses with a geometric mean 80% inhibitory concentration (IC80) of 29.75\u00a0\u00b5g mL<jats:sup>\u22121<\/jats:sup> and inhibits X4\u2010tropic HIV\u20101 with an IC80 of 64.20\u00a0\u00b5g mL<jats:sup>\u22121<\/jats:sup>, and R5\u2010tropic HIV\u20101 with an IC80 of 16.39\u00a0\u00b5g mL<jats:sup>\u22121<\/jats:sup>. The new system also specifically delivers siRNA into the cytoplasm of HIV\u20101\u2010infected cells and exhibits evident gene silencing of <jats:italic>tat<\/jats:italic> and <jats:italic>rev<\/jats:italic>. Therefore, this new system can neutralize HIV\u20101 and deliver siRNA selectively into HIV\u20101\u2010infected cells and may be a promising therapeutic candidate for the precise therapy of HIV.<\/jats:p>","DOI":"10.1002\/advs.202300282","type":"journal-article","created":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T23:41:34Z","timestamp":1675899694000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Lymphocyte Membrane\u2010 and 12p1\u2010Dual\u2010Functionalized Nanoparticles for Free HIV\u20101 Trapping and Precise siRNA Delivery into HIV\u20101\u2010Infected Cells"],"prefix":"10.1002","volume":"10","author":[{"given":"Jinbang","family":"Zhang","sequence":"first","affiliation":[{"name":"State key Laboratory of Toxicology and Medical Countermeasure Department of Pharmaceutics Beijing Institute of Pharmacology and Toxicology  Beijing 100039 China"},{"name":"Pharmaceutical College Henan University  Kaifeng 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