{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T23:49:29Z","timestamp":1788997769202,"version":"build-2803163510"},"reference-count":49,"publisher":"Wiley","issue":"25","license":[{"start":{"date-parts":[[2023,7,9]],"date-time":"2023-07-09T00:00:00Z","timestamp":1688860800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","award":["347471"],"award-info":[{"award-number":["347471"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","award":["347473"],"award-info":[{"award-number":["347473"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Dermatitis herpetiformis (DH) is an inflammatory skin disorder often considered as an extra intestinal manifestation of celiac disease (CeD). Hallmarks of CeD and DH are auto\u2010antibodies to transglutaminase 2 (TG2) and transglutaminase 3 (TG3), respectively. DH patients have auto\u2010antibodies reactive with both transglutaminase enzymes. Here it is reported that in DH both gut plasma cells and serum auto\u2010antibodies are specific for either TG2 or TG3 with no TG2\u2013TG3 cross reactivity. By generating monoclonal antibodies from TG3\u2010specific duodenal plasma cells of DH patients, three conformational epitope groups are defined. Both TG2\u2010specific and TG3\u2010specific gut plasma cells have few immunoglobulin (Ig) mutations, and the two transglutaminase\u2010reactive populations show distinct selection of certain heavy and light chain V\u2010genes. Mass spectrometry analysis of TG3\u2010specific serum IgA corroborates preferential usage of\n                    <jats:italic>IGHV2\u20105<\/jats:italic>\n                    in combination with\n                    <jats:italic>IGKV4\u20101<\/jats:italic>\n                    . Collectively, these results demonstrate parallel induction of anti\u2010TG2 and anti\u2010TG3 auto\u2010antibody responses involving separate B\u2010cell populations in DH patients.\n                  <\/jats:p>","DOI":"10.1002\/advs.202300401","type":"journal-article","created":{"date-parts":[[2023,7,9]],"date-time":"2023-07-09T23:19:57Z","timestamp":1688944797000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Separate Gut Plasma Cell Populations Produce Auto\u2010Antibodies against Transglutaminase 2 and Transglutaminase 3 in Dermatitis Herpetiformis"],"prefix":"10.1002","volume":"10","author":[{"given":"Saykat","family":"Das","sequence":"first","affiliation":[{"name":"Department of Immunology Oslo University Hospital\u2010Rikshospitalet  Oslo 0372 Norway"},{"name":"KG Jebsen Coeliac Disease Research Centre Institute of Clinical Medicine University of Oslo  Oslo 0372 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorunn","family":"Stamnaes","sequence":"additional","affiliation":[{"name":"Department of Immunology Oslo University Hospital\u2010Rikshospitalet  Oslo 0372 Norway"},{"name":"KG Jebsen Coeliac Disease Research Centre Institute of Clinical Medicine University of Oslo  Oslo 0372 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esko","family":"Kemppainen","sequence":"additional","affiliation":[{"name":"Celiac Disease Research Centre Faculty of Medicine and Health Technology Tampere University  Tampere 33520 Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaisa","family":"Hervonen","sequence":"additional","affiliation":[{"name":"Celiac Disease Research Centre Faculty of Medicine and Health Technology Tampere University  Tampere 33520 Finland"},{"name":"Department of Dermatology Tampere University Hospital  Tampere 33520 Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Knut E. A.","family":"Lundin","sequence":"additional","affiliation":[{"name":"KG Jebsen Coeliac Disease Research Centre Institute of Clinical Medicine University of Oslo  Oslo 0372 Norway"},{"name":"Department of Gastroenterology Oslo University Hospital\u2010Rikshospitalet  Oslo 0372 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naveen","family":"Parmar","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Oslo and Institute of Clinical Medicine Oslo University Hospital\u2010Rikshospitalet  Oslo 0372 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frode L.","family":"Jahnsen","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Oslo and Institute of Clinical Medicine Oslo University Hospital\u2010Rikshospitalet  Oslo 0372 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f8rgen","family":"Jahnsen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Akershus University Hospital  L\u00f8renskog 1478 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katri","family":"Lindfors","sequence":"additional","affiliation":[{"name":"Celiac Disease Research Centre Faculty of Medicine and Health Technology Tampere University  Tampere 33520 Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teea","family":"Salmi","sequence":"additional","affiliation":[{"name":"Celiac Disease Research Centre Faculty of Medicine and Health Technology Tampere University  Tampere 33520 Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasmus","family":"Iversen","sequence":"additional","affiliation":[{"name":"Department of Immunology Oslo University Hospital\u2010Rikshospitalet  Oslo 0372 Norway"},{"name":"KG Jebsen Coeliac Disease Research Centre Institute of Clinical Medicine University of Oslo  Oslo 0372 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8860-704X","authenticated-orcid":false,"given":"Ludvig M.","family":"Sollid","sequence":"additional","affiliation":[{"name":"Department of Immunology Oslo University Hospital\u2010Rikshospitalet  Oslo 0372 Norway"},{"name":"KG Jebsen Coeliac Disease Research Centre Institute of Clinical Medicine University of Oslo  Oslo 0372 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,9]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-020-00584-2"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1996.03890320060010"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.13992"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.169.1.345"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.191.4.603"},{"key":"e_1_2_9_4_3","doi-asserted-by":"publisher","DOI":"10.1016\/0198-8859(92)90104-U"},{"key":"e_1_2_9_4_4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1997.tb02706.x"},{"key":"e_1_2_9_4_5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2022.07.007"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20011299"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1014"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathmechdis-031521-032634"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-010-0554-y"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e318216f2e5"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2656"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.41.6.851"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1300183"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1700169"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1901561116"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2849"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu12020467"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23062910"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20200852"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20161590"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2018.03.017"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.042454899"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/21.9.2055"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1407457111"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.669895"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.08.036"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI98819"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12092884"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1357-2725(01)00033-4"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells9091996"},{"key":"e_1_2_9_25_3","doi-asserted-by":"publisher","DOI":"10.1126\/science.1260419"},{"key":"e_1_2_9_25_4","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)32847-8"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.12.068"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-27743-1"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5699(98)01413-3"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2005.00283.x"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182919070"},{"key":"e_1_2_9_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-004-4109-9"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.17183"},{"key":"e_1_2_9_30_2","doi-asserted-by":"publisher","DOI":"10.1177\/2050640619844125"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2019.03.1150"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.13907"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2022.05.010"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2007.09.017"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkn316"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1511"}],"updated-by":[{"DOI":"10.1002\/advs.202400894","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T00:00:00Z","timestamp":1710288000000}}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202300401","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T17:10:49Z","timestamp":1759770649000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202300401"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,9]]},"references-count":49,"journal-issue":{"issue":"25","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1002\/advs.202300401"],"URL":"https:\/\/doi.org\/10.1002\/advs.202300401","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.05.31.542741","asserted-by":"object"}]},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,9]]},"assertion":[{"value":"2023-01-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2300401"}}