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This study retains the advantages of drug loading and mechanical properties of natural 3D bioactive scaffolds. The scaffolds are functionally modified through chemical and self\u2010assembly approaches with application of polydopamine (PDA) nanoparticles and parathyroid hormone\u2010related peptide\u20101 (PTHrP\u20101) for efficient local drug loading. This study investigates the effects of the novel bioactive scaffolds on ossification, osteoclastogenesis, and macrophage polarization. This work elucidates the effects of the scaffolds in regulating osteoclastic activity and new bone formation in vitro. Further studies on the establishment and repair of OP bone defects in small animals are conducted, and the potential of natural bioactive porous scaffold materials to promote the repair of OP bone defects is initially verified. The preparation of safe and economical anti\u2010OP bone repair material provides a theoretical basis for clinical translational applications.<\/jats:p>","DOI":"10.1002\/advs.202300516","type":"journal-article","created":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T17:36:30Z","timestamp":1685036190000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["A Recombinant Parathyroid Hormone\u2010Related Peptide Locally Applied in Osteoporotic Bone Defect"],"prefix":"10.1002","volume":"10","author":[{"given":"Yi","family":"Wang","sequence":"first","affiliation":[{"name":"Zhongnan Hospital of Wuhan University  Donghu Road 169 Wuhan 430071 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingkun","family":"Hu","sequence":"additional","affiliation":[{"name":"Zhongnan Hospital of Wuhan University  Donghu Road 169 Wuhan 430071 P. R. 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