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The drugs eluted from these devices are non\u2010specific anti\u2010proliferative drugs, such as paclitaxel (PTX) or sirolimus (SMS), which do not address the underlying inflammation. MCC950 is a selective inhibitor of the NLRP3\u2010inflammasome, which drives sterile inflammation commonly observed in NIH. Additionally, in contrast to broad\u2010spectrum anti\u2010inflammatory drugs, MCC950 does not compromise global immune function due this selective activity. In this study, MCC950 is found to not impact the viability, integrity, or function of human coronary endothelial cells, in contrast to the non\u2010specific anti\u2010proliferative effects of PTX and SMS. Using an in vitro model of NLRP3\u2010mediated inflammation in murine macrophages, MCC950 reduced IL\u20101<jats:italic>\u03b2<\/jats:italic> expression, which is a key driver of NIH. In an in vivo mouse model of NIH in vascular grafts, MCC950 significantly enhanced re\u2010endothelialization and reduced NIH compared to PTX or SMS. These findings show the effectiveness of a targeted anti\u2010inflammatory drug\u2010elution strategy with significant implications for cardiovascular device intervention.<\/jats:p>","DOI":"10.1002\/advs.202300521","type":"journal-article","created":{"date-parts":[[2023,5,7]],"date-time":"2023-05-07T23:44:21Z","timestamp":1683503061000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Selective NLRP3 Inflammasome Inhibitor MCC950 Suppresses Inflammation and Facilitates Healing in Vascular Materials"],"prefix":"10.1002","volume":"10","author":[{"given":"Angus J.","family":"Grant","sequence":"first","affiliation":[{"name":"School of Medical Sciences Faculty of Health and Medicine Charles Perkins Centre University of Sydney  Sydney NSW 2006 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nianji","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Medical Sciences Faculty of Health and Medicine Charles Perkins Centre University of Sydney  Sydney NSW 2006 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Moore","sequence":"additional","affiliation":[{"name":"School of Medical Sciences Faculty of Health and Medicine Charles Perkins Centre University of Sydney  Sydney NSW 2006 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuen Ting","family":"Lam","sequence":"additional","affiliation":[{"name":"School of Medical Sciences Faculty of Health and Medicine Charles Perkins Centre University of Sydney  Sydney NSW 2006 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praveesuda L.","family":"Michael","sequence":"additional","affiliation":[{"name":"School of Medical Sciences Faculty of Health and Medicine Charles Perkins Centre University of Sydney  Sydney NSW 2006 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex H.P.","family":"Chan","sequence":"additional","affiliation":[{"name":"School of Medical Sciences Faculty of Health and Medicine Charles Perkins Centre University of Sydney  Sydney NSW 2006 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Santos","sequence":"additional","affiliation":[{"name":"School of Medical Sciences Faculty of Health and Medicine Charles Perkins Centre University of Sydney  Sydney NSW 2006 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jelena","family":"Rnjak\u2010Kovacina","sequence":"additional","affiliation":[{"name":"Graduate School of Biomedical Engineering University of New South Wales  Sydney NSW 2006 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard P.","family":"Tan","sequence":"additional","affiliation":[{"name":"School of Medical Sciences Faculty of Health and Medicine Charles Perkins Centre University of Sydney  Sydney NSW 2006 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7964-819X","authenticated-orcid":false,"given":"Steven G.","family":"Wise","sequence":"additional","affiliation":[{"name":"School of Medical Sciences Faculty of Health and Medicine Charles Perkins Centre University of Sydney  Sydney NSW 2006 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,7]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.303503"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.2147\/vhrm.1.1.73.58932"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2021.04.008"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.110.957332"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.15420\/ecr.2018:8:2"},{"key":"e_1_2_9_6_1","first-page":"279","volume":"8","author":"Zhang D.","year":"2014","journal-title":"Drug Des., Dev. 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