{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T01:02:41Z","timestamp":1791939761139,"version":"4.3.4"},"reference-count":59,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2023,6,5]],"date-time":"2023-06-05T00:00:00Z","timestamp":1685923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270716"],"award-info":[{"award-number":["82270716"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070698"],"award-info":[{"award-number":["82070698"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870464"],"award-info":[{"award-number":["81870464"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270764"],"award-info":[{"award-number":["82270764"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82022009"],"award-info":[{"award-number":["82022009"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271188"],"award-info":[{"award-number":["82271188"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Increased levels of circulating cell\u2010free DNA (cfDNA) are associated with poor clinical outcomes in patients with acute kidney injury (AKI). Scavenging cfDNA by nanomaterials is regarded as a promising remedy for cfDNA\u2010associated diseases, but a nanomaterial\u2010based cfDNA scavenging strategy has not yet been reported for AKI treatment. Herein, polyglycerol\u2010amine (PGA)\u2010covered MoS<jats:sub>2<\/jats:sub> nanosheets with suitable size are synthesized to bind negatively charged cfDNA in vitro, in vivo and ex vivo models. The nanosheets exhibit higher cfDNA binding capacity than polymer PGA and PGA\u2010based nanospheres owing to the flexibility and crimpability of their 2D backbone. Moreover, with low cytotoxicity and mild protein adsorption, the nanosheets effectively reduced serum cfDNA levels and predominantly accumulated in the kidneys to inhibit the formation of neutrophil extracellular traps and renal inflammation, thereby alleviating both lipopolysaccharide and ischemia\u2010reperfusion induced AKI in mice. Further, they decreased the serum cfDNA levels in samples from AKI patients. Thus, PGA\u2010covered MoS<jats:sub>2<\/jats:sub> nanosheets can serve as a potent cfDNA scavenger for treating AKI and other cfDNA\u2010associated diseases. In addition, this work demonstrates the pivotal feature of a 2D sheet\u2010like structure in the development of the cfDNA scavenger, which can provide a new insight into the future design of nanoplatforms for modulating inflammation.<\/jats:p>","DOI":"10.1002\/advs.202300604","type":"journal-article","created":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T20:03:07Z","timestamp":1686168187000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Polyglycerol\u2010Amine Covered Nanosheets Target Cell\u2010Free DNA to Attenuate Acute Kidney Injury"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9403-9656","authenticated-orcid":false,"given":"Kefei","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Nephrology\uff0c The First Affiliated Hospital\uff0c Sun Yat\u2010sen University NHC Key Laboratory of Clinical Nephrology Guangdong Provincial Key Laboratory of Nephrology  Guangzhou Guangdong 510080 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Nephrology\uff0c The First Affiliated Hospital\uff0c Sun Yat\u2010sen University NHC Key Laboratory of Clinical Nephrology Guangdong Provincial Key Laboratory of Nephrology  Guangzhou Guangdong 510080 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nephrology\uff0c The First Affiliated Hospital\uff0c Sun Yat\u2010sen University NHC Key Laboratory of Clinical Nephrology Guangdong Provincial Key Laboratory of Nephrology  Guangzhou Guangdong 510080 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yating","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nephrology\uff0c The First Affiliated Hospital\uff0c Sun Yat\u2010sen University NHC Key Laboratory of Clinical Nephrology Guangdong Provincial Key Laboratory of Nephrology  Guangzhou Guangdong 510080 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology the Sixth Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou Guangdong 510655 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nephrology\uff0c The First Affiliated Hospital\uff0c Sun Yat\u2010sen University NHC Key Laboratory of Clinical Nephrology Guangdong Provincial Key Laboratory of Nephrology  Guangzhou Guangdong 510080 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiyan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nephrology\uff0c The First Affiliated Hospital\uff0c Sun Yat\u2010sen University NHC Key Laboratory of Clinical Nephrology Guangdong Provincial Key Laboratory of Nephrology  Guangzhou Guangdong 510080 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghua","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nephrology\uff0c The First Affiliated Hospital\uff0c Sun Yat\u2010sen University NHC Key Laboratory of Clinical Nephrology Guangdong Provincial Key Laboratory of Nephrology  Guangzhou Guangdong 510080 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Shao","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences and Engineering South China University of Technology Guangzhou International Campus  Guangzhou Guangdong 511442 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Nephrology\uff0c The First Affiliated Hospital\uff0c Sun Yat\u2010sen University NHC Key Laboratory of Clinical Nephrology Guangdong Provincial Key Laboratory of Nephrology  Guangzhou Guangdong 510080 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Nephrology\uff0c The First Affiliated Hospital\uff0c Sun Yat\u2010sen University NHC Key Laboratory of Clinical Nephrology Guangdong Provincial Key Laboratory of Nephrology  Guangzhou Guangdong 510080 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoxu","family":"Tu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology the Sixth Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou Guangdong 510655 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3608-3851","authenticated-orcid":false,"given":"Haiping","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Nephrology\uff0c The First Affiliated Hospital\uff0c Sun Yat\u2010sen University NHC Key Laboratory of Clinical Nephrology Guangdong Provincial Key Laboratory of Nephrology  Guangzhou Guangdong 510080 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,5]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2020.02.010"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-021-00452-0"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abb7422"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2017.06.030"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2012.04.006"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12454"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/9339411"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2016.71"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm11020151"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4332"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00138-18"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2017.09.031"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2016.08.006"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2015.214"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2017.107"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2016080925"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2017.08.014"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0218548"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000440975"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-54694-x"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000445546"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2110015"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.120389"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.51.7.750"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.12501019"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.11.050"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201813362"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06603-5"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.0c04759"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1105777108"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1607011113"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matt.2021.07.009"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201701837"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1735"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20100239"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b12083"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202000933"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201804291"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c02454"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.inoche.2020.108200"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1017\/erm.2017.12"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abj2372"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.10.044"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201400546"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmacrolett.6b00804"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7NR06588D"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1021\/nl0805615"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2019.06.026"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aay7148"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2006.07.024"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-022-09818-4"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2020.01.036"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-002-1418-z"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit036"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2017.07.003"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aaz6980"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.200902144"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b00516"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1TB02021H"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202300604","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T20:55:20Z","timestamp":1759784120000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202300604"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,5]]},"references-count":59,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1002\/advs.202300604"],"URL":"https:\/\/doi.org\/10.1002\/advs.202300604","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,5]]},"assertion":[{"value":"2023-01-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2300604"}}