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Although recent investigations have reported that infrapatellar fat pad (IPFP) can trigger inflammation in the knee joint, the mechanisms behind the role of IPFP on knee OA progression remain to be defined. Here, dysregulated osteopontin (OPN) and integrin\n                    <jats:italic>\u03b2<\/jats:italic>\n                    3 signaling are found in the OA specimens of both human and mice. It is further demonstrated that IPFP\u2010derived OPN participates in OA progression, including activated matrix metallopeptidase 9 in chondrocyte hypertrophy and integrin\n                    <jats:italic>\u03b2<\/jats:italic>\n                    3 in IPFP fibrosis. Motivated by these findings, an injectable nanogel is fabricated to provide sustained release of siRNA\n                    <jats:italic>Cd61<\/jats:italic>\n                    (\n                    <jats:sup>RGD\u2212<\/jats:sup>\n                    Nanogel\/siRNA\n                    <jats:italic>Cd61<\/jats:italic>\n                    ) that targets integrins. The\n                    <jats:sup>RGD\u2212<\/jats:sup>\n                    Nanogel possesses excellent biocompatibility and desired targeting abilities both in vitro and in vivo. Local injection of\n                    <jats:sup>RGD\u2212<\/jats:sup>\n                    Nanogel\/siRNA\n                    <jats:italic>Cd61<\/jats:italic>\n                    robustly alleviates the cartilage degeneration, suppresses the advancement of tidemark, and reduces the subchondral trabecular bone mass in OA mice. Taken together, this study provides an avenue for developing\n                    <jats:sup>RGD\u2212<\/jats:sup>\n                    Nanogel\/siRNA\n                    <jats:italic>Cd61<\/jats:italic>\n                    therapy to mitigate OA progression via blocking OPN\u2010integrin\n                    <jats:italic>\u03b2<\/jats:italic>\n                    3 signaling in IPFP.\n                  <\/jats:p>","DOI":"10.1002\/advs.202300897","type":"journal-article","created":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T04:44:18Z","timestamp":1684817058000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Blockage of Osteopontin\u2010Integrin\n                    <i>\u03b2<\/i>\n                    3 Signaling in Infrapatellar Fat Pad Attenuates Osteoarthritis in Mice"],"prefix":"10.1002","volume":"10","author":[{"given":"Bingyang","family":"Dai","sequence":"first","affiliation":[{"name":"Musculoskeletal Research Laboratory of Department of Orthopaedics &amp; Traumatology and Innovative Orthopaedic Biomaterial &amp; Drug Translational Research Laboratory Li Ka Shing Institute of Health Sciences The Chinese University of Hong Kong  Hong Kong 999077 China"},{"name":"Areas of Excellence Centre for Musculoskeletal Degeneration and Regeneration Department of Orthopaedics and Traumatology Faculty of Medicine The Chinese University of Hong Kong  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuwei","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Chemistry The Chinese University of Hong Kong  Hong Kong 999077 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Li","sequence":"additional","affiliation":[{"name":"Musculoskeletal Research Laboratory of Department of 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