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However, the limited local O\n                    <jats:sub>2<\/jats:sub>\n                    \/H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    production and post\u2010treatment inflammation remain long\u2010standing issues. To address these challenges, a novel H\n                    <jats:sub>2<\/jats:sub>\n                    \u2010evolving bio\u2010heterojunction enzyme (Bio\u2010HJzyme) consisting of graphite\u2010phase carbon nitride\/copper sulfide (CN\/Cu\n                    <jats:sub>\n                      2\u2212\n                      <jats:italic>x<\/jats:italic>\n                    <\/jats:sub>\n                    S) heterojunction and glucose oxidase (GO\n                    <jats:italic>x<\/jats:italic>\n                    ) is created. The Bio\u2010HJzyme offers glutathione peroxidase (GP\n                    <jats:italic>x<\/jats:italic>\n                    ), peroxidase (POD), and catalase (CAT) mimetic activities; provides anti\u2010pathogen properties via programmed light activation; and effectively promotes diabetic wound healing. Specifically, its GP\n                    <jats:italic>x<\/jats:italic>\n                    \u2010mimetic activity and the presence of GO\n                    <jats:italic>x<\/jats:italic>\n                    significantly enhance the yield of H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    , which can be catalyzed through POD\u2010mimetic activity to produce highly germicidal \u2022OH. The H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    can also be catalyzed to H\n                    <jats:sub>2<\/jats:sub>\n                    O and O\n                    <jats:sub>2<\/jats:sub>\n                    , assisted by the CAT\u2010mimetic activity. The catalyzed products can then be catalyzed into germicidal \u2022OH and \u2022O\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>\u2212<\/jats:sup>\n                    under NIR light irradiation, giving enhanced ADT. Further, CN can split water to form H\n                    <jats:sub>2<\/jats:sub>\n                    under solar light, which dramatically suppresses the inflammation caused by excessive ROS. In vivo evaluation confirms that Bio\u2010HJzyme promotes the regeneration of diabetic infectious skin through killing bacteria, enhancing angiogenesis, promoting wound bed epithelialization, and reinforcing anti\u2010inflammatory responses; hence, providing a revolutionary approach for diabetic wounds healing.\n                  <\/jats:p>","DOI":"10.1002\/advs.202300986","type":"journal-article","created":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T00:09:38Z","timestamp":1683763778000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Multi\u2010Functional Bio\u2010HJzyme: Revolutionizing Diabetic Skin Regeneration with its Glucose\u2010Unlocked Sterilization and Programmed Anti\u2010Inflammatory 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