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Surprisingly, computational deconvolution methods for high\u2010throughput chromosome conformation capture (Hi\u2010C) data remain very rare in the literature. Here, a deep convolutional neural network (CNN), deconvolve bulk Hi\u2010C data (deCOOC) that remarkably outperformed all the state\u2010of\u2010the\u2010art tools in the deconvolution task is developed. Interestingly, it is noticed that the chromatin accessibility or the Hi\u2010C contact frequency alone is insufficient to explain the power of deCOOC, suggesting the existence of a latent embedded layer of information pertaining to the cell type specific 3D genome architecture. By applying deCOOC to in\u2010house\u2010generated bulk Hi\u2010C data from visceral and subcutaneous adipose tissues, it is found that the characteristic chromatin features of M2 cells in the two anatomical loci are distinctively bound to different physiological functionalities. Taken together, deCOOC is both a reliable Hi\u2010C data deconvolution method and a powerful tool for functional extraction of 3D genome architecture.<\/jats:p>","DOI":"10.1002\/advs.202301058","type":"journal-article","created":{"date-parts":[[2023,7,29]],"date-time":"2023-07-29T02:30:27Z","timestamp":1690597827000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["DeCOOC Deconvoluted Hi\u2010C Map Characterizes the Chromatin Architecture of Cells in Physiologically Distinctive Tissues"],"prefix":"10.1002","volume":"10","author":[{"given":"Junmei","family":"Wang","sequence":"first","affiliation":[{"name":"CAS Key Laboratory of Genome Sciences and Information Beijing Institute of Genomics Chinese Academy of Sciences and China National Center for Bioinformation  Beijing 100101 China"},{"name":"School of Life Science University of Chinese Academy of Sciences  Beijing 100049 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Lu","sequence":"additional","affiliation":[{"name":"Livestock and Poultry Multiomics Key Laboratory of Ministry of Agriculture and Rural Affairs College of Animal Science and Technology Sichuan Agricultural University  Chengdu 611130 China"},{"name":"Animal Breeding and Genetics Key Laboratory of Sichuan Province Institute of Animal Genetics and Breeding Sichuan Agricultural University  Chengdu 611130 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiqi","family":"Zheng","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Genome Sciences and Information Beijing Institute of Genomics Chinese Academy of Sciences and China National Center for Bioinformation  Beijing 100101 China"},{"name":"School of Life Science University of Chinese Academy of Sciences  Beijing 100049 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danyang","family":"Wang","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Genome Sciences and Information Beijing Institute of Genomics Chinese Academy of Sciences and China National Center for Bioinformation  Beijing 100101 China"},{"name":"School of Life Science University of Chinese Academy of Sciences  Beijing 100049 China"},{"name":"Sars\u2010Fang Centre &amp; MOE Key Laboratory of Marine Genetics and Breeding College of Marine Life Sciences Ocean University of China  Qingdao 266100 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Long","family":"Jin","sequence":"additional","affiliation":[{"name":"Livestock and Poultry Multiomics Key Laboratory of Ministry of Agriculture and Rural Affairs College of Animal Science and Technology Sichuan Agricultural University  Chengdu 611130 China"},{"name":"Animal Breeding and Genetics Key Laboratory of Sichuan Province Institute of Animal Genetics and Breeding Sichuan Agricultural University  Chengdu 611130 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Zhang","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Genome Sciences and Information Beijing Institute of Genomics Chinese Academy of Sciences and China National Center for Bioinformation  Beijing 100101 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingzhou","family":"Li","sequence":"additional","affiliation":[{"name":"Livestock and Poultry Multiomics Key Laboratory of Ministry of Agriculture and Rural Affairs College of Animal Science and Technology Sichuan Agricultural University  Chengdu 611130 China"},{"name":"Animal Breeding and Genetics Key Laboratory of Sichuan Province Institute of Animal Genetics and Breeding Sichuan Agricultural University  Chengdu 611130 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7706-9247","authenticated-orcid":false,"given":"Zhihua","family":"Zhang","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Genome Sciences and Information Beijing Institute of Genomics Chinese Academy of Sciences and China National Center for Bioinformation  Beijing 100101 China"},{"name":"School of Life Science University of Chinese Academy of Sciences  Beijing 100049 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,7,28]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00110-09"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/wdev.395"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02386-3"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.02.007"},{"key":"e_1_2_9_5_1","first-page":"535","volume":"20","author":"Zheng H.","year":"2019","journal-title":"Biol. 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