{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:59:54Z","timestamp":1792515594661,"version":"4.5.0"},"reference-count":39,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T00:00:00Z","timestamp":1683849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Multiple myeloma (MM) is a cancer of differentiated plasma cells that occurs in the bone marrow (BM). Despite the recent advancements in drug development, most patients with MM eventually relapse and the disease remains incurable. RNA therapy delivered via lipid nanoparticles (LNPs) has the potential to be a promising cancer treatment, however, its clinical implementation is limited due to inefficient delivery to non\u2010hepatic tissues. Here, targeted (t)LNPs designed for delivery of RNA payload to MM cells are presented. The tLNPs consist of a novel ionizable lipid and are coated with an anti\u2010CD38 antibody (\n                    <jats:italic>\u03b1<\/jats:italic>\n                    CD38\u2010tLNPs). To explore their therapeutic potential, it is demonstrated that LNPs encapsulating small interference RNA (siRNA) against cytoskeleton\u2010associated protein 5 (CKAP5) lead to a \u224890% decrease in cell viability of MM cells in vitro. Next, a new xenograft MM mouse model is employed, which clinically resembles the human disease and demonstrates efficient homing of MM cells to the BM. Specific delivery of\n                    <jats:italic>\u03b1<\/jats:italic>\n                    CD38\u2010tLNPs to BM\u2010residing and disseminated MM cells and the improvement in therapeutic outcome of MM\u2010bearing mice treated with\n                    <jats:italic>\u03b1<\/jats:italic>\n                    CD38\u2010tLNPs\u2010siRNA\u2010CKAP5 are shown. These results underscore the potential of RNA therapeutics for treatment of MM and the importance of developing effective targeted delivery systems and reliable preclinical models.\n                  <\/jats:p>","DOI":"10.1002\/advs.202301377","type":"journal-article","created":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T11:31:09Z","timestamp":1683891069000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Delivery of Therapeutic RNA to the Bone Marrow in Multiple Myeloma Using CD38\u2010Targeted Lipid Nanoparticles"],"prefix":"10.1002","volume":"10","author":[{"given":"Dana","family":"Tarab\u2010Ravski","sequence":"first","affiliation":[{"name":"Laboratory of Precision NanoMedicine The Shmunis School of Biomedicine and Cancer Research George S. Wise Faculty of Life Sciences Tel Aviv University  Tel Aviv 69978 Israel"},{"name":"Department of Materials Sciences and Engineering Iby and Aladar Fleischman Faculty of Engineering Tel Aviv University  Tel Aviv 69978 Israel"},{"name":"Center for Nanoscience and Nanotechnology Tel Aviv University  Tel Aviv 69978 Israel"},{"name":"Cancer Biology Research Center Tel Aviv University  Tel Aviv 69978 Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inbal","family":"Hazan\u2010Halevy","sequence":"additional","affiliation":[{"name":"Laboratory of Precision NanoMedicine The Shmunis School of Biomedicine and Cancer Research George S. Wise Faculty of Life Sciences Tel Aviv University  Tel Aviv 69978 Israel"},{"name":"Department of Materials Sciences and Engineering Iby and Aladar Fleischman Faculty of Engineering Tel Aviv University  Tel Aviv 69978 Israel"},{"name":"Center for Nanoscience and Nanotechnology Tel Aviv University  Tel Aviv 69978 Israel"},{"name":"Cancer Biology Research Center Tel Aviv University  Tel Aviv 69978 Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meir","family":"Goldsmith","sequence":"additional","affiliation":[{"name":"Laboratory of Precision NanoMedicine The Shmunis School of Biomedicine and Cancer Research George S. Wise Faculty of Life Sciences Tel Aviv University  Tel Aviv 69978 Israel"},{"name":"Department of Materials Sciences and Engineering Iby and Aladar Fleischman Faculty of Engineering Tel Aviv University  Tel Aviv 69978 Israel"},{"name":"Center for Nanoscience and Nanotechnology Tel Aviv University  Tel Aviv 69978 Israel"},{"name":"Cancer Biology Research Center Tel Aviv University  Tel Aviv 69978 Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lior","family":"Stotsky\u2010Oterin","sequence":"additional","affiliation":[{"name":"Laboratory of Precision NanoMedicine The Shmunis School of Biomedicine and Cancer Research George S. Wise Faculty of Life Sciences Tel Aviv University  Tel Aviv 69978 Israel"},{"name":"Department of Materials Sciences and Engineering Iby and Aladar Fleischman Faculty of Engineering Tel Aviv University  Tel Aviv 69978 Israel"},{"name":"Center for Nanoscience and Nanotechnology Tel Aviv University  Tel Aviv 69978 Israel"},{"name":"Cancer Biology Research Center Tel Aviv University  Tel Aviv 69978 Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dor","family":"Breier","sequence":"additional","affiliation":[{"name":"Laboratory of Precision NanoMedicine The Shmunis School of Biomedicine and Cancer Research George S. Wise Faculty of Life Sciences Tel Aviv University  Tel Aviv 69978 Israel"},{"name":"Department of Materials Sciences and Engineering Iby and Aladar Fleischman Faculty of Engineering Tel Aviv University  Tel Aviv 69978 Israel"},{"name":"Center for Nanoscience and Nanotechnology Tel Aviv University  Tel Aviv 69978 Israel"},{"name":"Cancer Biology Research Center Tel Aviv University  Tel Aviv 69978 Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonna Somu","family":"Naidu","sequence":"additional","affiliation":[{"name":"Laboratory of Precision NanoMedicine The Shmunis School of Biomedicine and Cancer Research George S. Wise Faculty of Life Sciences Tel Aviv University  Tel Aviv 69978 Israel"},{"name":"Department of Materials Sciences and Engineering Iby and Aladar Fleischman Faculty of Engineering Tel Aviv University  Tel Aviv 69978 Israel"},{"name":"Center for Nanoscience and Nanotechnology Tel Aviv University  Tel Aviv 69978 Israel"},{"name":"Cancer Biology Research Center Tel Aviv University  Tel Aviv 69978 Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjaiah","family":"Aitha","sequence":"additional","affiliation":[{"name":"Laboratory of Precision NanoMedicine The Shmunis School of Biomedicine and Cancer Research George S. 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