{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:28:28Z","timestamp":1791908908299,"version":"4.3.4"},"reference-count":27,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T00:00:00Z","timestamp":1686009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070408"],"award-info":[{"award-number":["82070408"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82000380"],"award-info":[{"award-number":["82000380"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870269"],"award-info":[{"award-number":["81870269"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2016YFC1301200"],"award-info":[{"award-number":["2016YFC1301200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Mesenchymal stem cell\u2010derived extracellular vesicle (MSC\u2010EV) is shown to promote cardiac repair, however, it still falls short in initiating myocardia proliferation restart. In this regard, ROS\u2010induced DNA damage and responses are the culprit of cellcycle arrest. Here, this work\u00a0constructs a hybrid cell\u2010derived extracellular vesicle that is composed of MSC and macrophage membranes and encompasses MitoN, a ROS scavenger, to boost the healing of the heart. The MitoN, a NAD(P)H mimic, could\u00a0target the mitochondrial to eliminate the ROS resuming the arrested cell cycle. The hybrid extracellular vesicle (N@MEV) could\u00a0respond to the inflammatory signals generated during myocardial injury and thus enable superior targeting and enrichment to the location of the damage. L\u2010arginine, which could be catalyzed by NOS and ROS into NO and SO provide a driving force, is\u00a0immobilized within the vesicle (NA@MEV) to further enhance the N@MEV's potential to penetrate the cardiac stroma. In combination with multiple mechanisms, NA@MEV increased heart function 1.3\u2010fold EF% versus\u00a0MSC\u2010EV in mouse myocardial injury model. A more in\u2010depth mechanistic study found that the NA@MEV could\u00a0modulate M2 macrophage; promote angiogenesis; reduce DNA damage and response, and thereby restart cardiomyocyte proliferation. Thus, this combined therapy shows synthetic effects in heart repair and regeneration.<\/jats:p>","DOI":"10.1002\/advs.202301440","type":"journal-article","created":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T11:34:23Z","timestamp":1686137663000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Biomimetic and NOS\u2010Responsive Nanomotor Deeply Delivery a Combination of MSC\u2010EV and Mitochondrial ROS Scavenger and Promote Heart Repair and Regeneration"],"prefix":"10.1002","volume":"10","author":[{"given":"Ning","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Cardiology Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province Sir Run Run Shaw Hospital Zhejiang University School of Medicine  Hangzhou 310016 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengkang","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Cardiology Affiliated Hospital of Nantong University  Nantong 226001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongchao","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Cardiology Zhongshan Hospital Fudan University Shanghai Institute of Cardiovascular Diseases  Shanghai 200032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolong","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province Sir Run Run Shaw Hospital Zhejiang University School of Medicine  Hangzhou 310016 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiongjun","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province Sir Run Run Shaw Hospital Zhejiang University School of Medicine  Hangzhou 310016 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolu","family":"Jiao","sequence":"additional","affiliation":[{"name":"Department of Cardiology Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province Sir Run Run Shaw Hospital Zhejiang University School of Medicine  Hangzhou 310016 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingbo","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Cardiology Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province Sir Run Run Shaw Hospital Zhejiang University School of Medicine  Hangzhou 310016 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duanbin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province Sir Run Run Shaw Hospital Zhejiang University School of Medicine  Hangzhou 310016 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheyong","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Zhongshan Hospital Fudan University Shanghai Institute of Cardiovascular Diseases  Shanghai 200032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guosheng","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province Sir Run Run Shaw Hospital Zhejiang University School of Medicine  Hangzhou 310016 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junbo","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Cardiology Zhongshan Hospital Fudan University Shanghai Institute of Cardiovascular Diseases  Shanghai 200032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1765-8445","authenticated-orcid":false,"given":"Hongjun","family":"Li","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences Zhejiang Laboratory of Systems and Precision Medicine Zhejiang University Hangzhou 310012 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province Sir Run Run Shaw Hospital Zhejiang University School of Medicine  Hangzhou 310016 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,6]]},"reference":[{"key":"e_1_2_8_1_1","first-page":"659","volume":"15","author":"Menasche P.","year":"2018","journal-title":"Cardiology"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aat9365"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.306593"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.307654"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.03.032"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14582"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature20173"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.4330\/wjc.v10.i9.74"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2019.03.038"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18112233"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201911508"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13316-w"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat4644"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2012.212"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c03177"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/8364848"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.120168"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.52496"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht331"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20070885"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12013-021-01011-x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.7b09107"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2018.11.010"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-03-492504"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2016.02.006"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2019.08.009"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.2983"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202301440","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T21:25:51Z","timestamp":1759785951000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202301440"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,6]]},"references-count":27,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["10.1002\/advs.202301440"],"URL":"https:\/\/doi.org\/10.1002\/advs.202301440","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,6]]},"assertion":[{"value":"2023-03-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2301440"}}