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Herein, inspired by multiple creatures, including octopuses and snails, a novel muti\u2010functional hydrogel patch is presented with controlled adhesion, antibacterial, drug release features, and multiple monitoring functions for intelligent wound healing management. The patch with micro suction\u2010cup actuator array and a tensile backing layer is composed of tannin grafted gelatin, Ag\u2010tannin nanoparticles, polyacrylamide (PAAm) and poly(<jats:italic>N<\/jats:italic>\u2010isopropylacrylamide) (PNIPAm). In virtue of the photothermal gel\u2010sol transition of tannin grafted gelatin and Ag\u2010tannin nanoparticles, the patches exert a dual anti\u2010microbial effect and temperature\u2010sensitive snail mucus\u2010like features. In addition, as the \u201csuction\u2010cups\u201d consisting of thermal responsive PNIPAm can undergo a contract\u2010relax transformation, the medical patches can adhere to the objects reversibly and responsively, and release their loaded vascular endothelial growth factor (VEGF) controllably for wound healing. More attractively, benefiting from their fatigue resistance, self\u2010healing ability of the tensile double network hydrogel, and electrical conductivity of Ag\u2010tannin nanoparticles, the proposed patches can report multiple wound physiology parameters sensitively and continuously. Thus, it is believed that this multi\u2010bioinspired patch has immense potential for future wound healing management.<\/jats:p>","DOI":"10.1002\/advs.202301479","type":"journal-article","created":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T02:45:48Z","timestamp":1687920348000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":117,"title":["Multi\u2010Bioinspired Functional Conductive Hydrogel Patches for Wound Healing Management"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5976-0069","authenticated-orcid":false,"given":"Wenzhao","family":"Li","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital School of Biological Science and Medical Engineering Southeast University  Nanjing 210096 China"},{"name":"Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou Institute University of Chinese Academy of Sciences  Wenzhou Zhejiang 325001 China"},{"name":"Department of Biomedical Engineering The Hong Kong Polytechnic University  Hong Kong SAR 999077 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunru","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital School of Biological Science and Medical Engineering Southeast University  Nanjing 210096 China"},{"name":"Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou Institute University of Chinese Academy of Sciences  Wenzhou Zhejiang 325001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongkang","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of General Surgery and Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangdong Institute of Gastroenterology The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangdong 510655 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaocheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital School of Biological Science and Medical Engineering Southeast University  Nanjing 210096 China"},{"name":"Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou Institute University of Chinese Academy of Sciences  Wenzhou Zhejiang 325001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puxiang","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering The Hong Kong Polytechnic University  Hong Kong SAR 999077 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Shanghai Changhai Hospital Naval Medical University  Shanghai 200433 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