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In the present study, a murine osteoarthritic model with augmented neurovascularization at the osteochondral junction is used to examine this under\u2010evaluated facet of degenerative joint dysfunction. Increased extracellular RNA (exRNA) content is identified in neurovascularized osteoarthritic joints. It is found that the amount of exRNA is positively correlated with the extent of neurovascularization and the expression of vascular endothelial growth factor (VEGF). In vitro binding assay and molecular docking demonstrate that synthetic RNAs bind to VEGF via electrostatic interactions. The RNA\u2010VEGF complex promotes the migration and function of endothelial progenitor cells and trigeminal ganglion cells. The use of VEGF and VEGFR2 inhibitors significantly inhibits the amplification of the RNA\u2010VEGF complex. Disruption of the RNA\u2010VEGF complex by RNase and polyethyleneimine reduces its in vitro activities, as well as prevents excessive neurovascularization and osteochondral deterioration in vivo. The results of the present study suggest that exRNAs may be potential targets for regulating nerve and blood vessel ingrowth under physiological and pathological joint conditions.<\/jats:p>","DOI":"10.1002\/advs.202301763","type":"journal-article","created":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T07:20:54Z","timestamp":1688368854000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Effect of Extracellular Ribonucleic Acids on Neurovascularization in Osteoarthritis"],"prefix":"10.1002","volume":"10","author":[{"given":"Wen\u2010pin","family":"Qin","sequence":"first","affiliation":[{"name":"Department of Stomatology Tangdu hospital The Fourth Military Medical University  Xi'an Shaanxi 710032 P. R. 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