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To detect low abundance of intracellular oncogenic miRNAs (onco\u2010miRNAs) and realize synergistic gene therapy of onco\u2010miRNAs and tumor suppressors, a smart nano\u2010theranostic platform based on dual\u2010miRNAs guided self\u2010feedback tetrahedral entropy\u2010driven DNA circuit is created. The platform as a delivery vehicle is a DNA tetrahedral framework, in which the entropy\u2010driven DNA circuit achieves a dual\u2010miRNAs guided self\u2010feedback, between an in situ amplification of the onco\u2010miRNAs and activation of suppressor miRNAs release. To test this platform, dual\u2010miRNAs are selected, miRNA\u2010155, an up\u2010regulated miRNA, as cancer indicators, and miRNA\u2010122, a down\u2010regulated miRNA as therapy targets in hepatocellular carcinoma, respectively. Through the circuit, the platform to detect onco\u2010miRNAs at femtomolar level as well as visualized miRNAs inside cells, fixed tissues, and mice is programmed. Furthermore, triggered by miRNA\u2010155, preloaded miRNA\u2010122 is amplified via the self\u2010feedback and released into target cells; the sudden increase of miRNA\u2010122 and simultaneous decrease of miRNA\u2010155 synergistically served as therapeutic drugs for gene regulation with enhanced antitumor efficacy and superior biosafety. It is envisioned that this nano\u2010theranostic platform will initiate an essential step toward tumor theranostics in personalized\/precise medicine.<\/jats:p>","DOI":"10.1002\/advs.202301814","type":"journal-article","created":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T23:11:59Z","timestamp":1682118719000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["A Smart Nano\u2010Theranostic Platform Based on Dual\u2010microRNAs Guided Self\u2010Feedback Tetrahedral Entropy\u2010Driven DNA Circuit"],"prefix":"10.1002","volume":"10","author":[{"given":"Sha","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory Medicine Southwest Hospital Third Military Medical University (Army Medical University)  30 Gaotanyan, Shapingba District Chongqing 400038 P. R. 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