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While significant efforts have been devoted to develop nanostructured MEAs for improving the electrophysiological investigation in neurons and cardiomyocytes, data on the recording of the electrical activity from neuroendocrine cells with MEA technology are scarce owing to their weaker electrical signals. Disordered silicon nanowires (SiNWs) for developing a MEA that, combined with a customized acquisition board, successfully capture the electrical signals generated by the corticotrope AtT\u201020\u00a0cells as a function of the extracellular calcium (Ca<jats:sup>2+<\/jats:sup>) concentration are reported. The recorded signals show a shape that clearly resembles the action potential waveform by suggesting a natural membrane penetration of the SiNWs. Additionally, the generation of synchronous signals observed under high Ca<jats:sup>2+<\/jats:sup> content indicates the occurrence of a collective behavior in the AtT\u201020\u00a0cell population. This study extends the usefulness of MEA technology to the investigation of the electrical communication in cells of the pituitary gland, crucial in controlling several essential human functions, and provides new perspectives in recording with MEA the electrical activity of excitable cells.<\/jats:p>","DOI":"10.1002\/advs.202301925","type":"journal-article","created":{"date-parts":[[2023,6,25]],"date-time":"2023-06-25T22:09:17Z","timestamp":1687730957000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Revealing Low Amplitude Signals of Neuroendocrine Cells through Disordered Silicon Nanowires\u2010Based Microelectrode Array"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0822-2850","authenticated-orcid":false,"given":"Francesco","family":"Maita","sequence":"first","affiliation":[{"name":"Institute for Microelectronics and Microsystems National Research Council  Via Fosso del 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