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However, this strategy is greatly compromised by the powerful antioxidant capacity of tumors and the limited ROS generation rate of nanomedicines. This dilemma mainly stems from the lack of an effective synthesis method to support high\u2010density copper\u2010based nanocatalysts on the surface of photothermal nanomaterials. Herein, a multifunctional nanoplatform (MCPQZ) with high\u2013density cuprous (Cu<jats:sub>2<\/jats:sub>O) supported molybdenum disulfide (MoS<jats:sub>2<\/jats:sub>) nanoflowers (MC NFs) is developed for the efficient killing of tumors via a potent ROS storm by an innovative method. Under NIR\u2010II light irradiation, the ROS intensity and maximum reaction velocity (<jats:italic>V<\/jats:italic><jats:sub>max<\/jats:sub>) produced by MC NFs are\u00a021.6\u00a0and 33.8\u00a0times that of the non\u2013irradiation group\u00a0in vitro, which is much higher than most current nanomedicines. Moreover, the strong ROS storm in cancer cells is\u00a0efficiently formed by MCPQZ (increased by 27.8\u00a0times compared to the control), thanks to the fact that MCPQZ effectively pre\u2013weakens the multiple antioxidant systems of cancer cells. This work provides a novel insight to solve the bottleneck of ROS\u2010based cancer therapy.<\/jats:p>","DOI":"10.1002\/advs.202302208","type":"journal-article","created":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T00:50:58Z","timestamp":1687308658000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["A NIR\u2010II Photoactivatable \u201cROS Bomb\u201d with High\u2010Density Cu<sub>2<\/sub>O\u2010Supported MoS<sub>2<\/sub> Nanoflowers for Anticancer Therapy"],"prefix":"10.1002","volume":"10","author":[{"given":"Jia","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Pharmacy Xiangya Hospital Central South University  Changsha 410008 China"},{"name":"Department of Pharmacology, Xiangya School of Pharmaceutical Sciences Central South University  Changsha 410078 China"},{"name":"Hunan Provincial Key Laboratory of Cardiovascular Research Xiangya School of Pharmaceutical Sciences Central 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