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Typical conductive materials such as polypyrrole (PPy) are commonly used to fabricate artificial nerve conduits. Moreover, the field of tissue engineering has advanced toward the use of products such as hyaluronic acid (HA) hydrogels. Although HA\u2010modified PPy films are prepared for various biological applications, the cell\u2013matrix interaction mechanisms remain poorly understood; furthermore, there are no reports on HA\u2010modified PPy\u2010injectable self\u2010healing hydrogels for peripheral nerve repair. Therefore, in this study, a self\u2010healing electroconductive hydrogel (HASPy) from HA, cystamine (Cys), and pyrrole\u20101\u2010propionic acid (Py\u2010COOH), with injectability, biodegradability, biocompatibility, and nerve\u2010regenerative capacity is constructed. The hydrogel directly targets interleukin 17 receptor A (IL\u201017RA) and promotes the expression of genes and proteins relevant to Schwann cell myelination mainly by activating the interleukin 17 (IL\u201017) signaling pathway. The hydrogel is injected directly into the rat sciatic nerve\u2010crush injury sites to investigate its capacity for nerve regeneration in vivo and is found to promote functional recovery and remyelination. This study may help in understanding the mechanism of cell\u2013matrix interactions and provide new insights into the potential use of HASPy hydrogel as an advanced scaffold for neural regeneration.<\/jats:p>","DOI":"10.1002\/advs.202302519","type":"journal-article","created":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T23:56:15Z","timestamp":1692834975000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":116,"title":["A Bioinspired Self\u2010Healing Conductive Hydrogel Promoting Peripheral Nerve Regeneration"],"prefix":"10.1002","volume":"10","author":[{"given":"Hongyun","family":"Xuan","sequence":"first","affiliation":[{"name":"School of Life Sciences Nantong University  Nantong Jiangsu 226019 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyuan","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Life Sciences Nantong University  Nantong Jiangsu 226019 P. R. 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