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Immunomodulatory properties of orthopedic biomaterials have significance in regulating osteoimmune microenvironment for osteogenesis. A lactic acid\u2010co\u2010glycolic acid (PLGA) scaffold incorporates black phosphorus (BP) fabricated by 3D printing technology to investigate the effect of BP on osteoimmunomodulation and osteogenesis in site. The PLGA\/BP scaffold exhibits suitable biocompatibility, biodegradability, and mechanical properties as an excellent microenvironment to support new bone formation. The studies' result also demonstrate that the PLGA\/BP scaffolds are able to recruit and stimulate macrophages M2\u00a0polarization, inhibit inflammation, and promote human bone marrow mesenchymal stem cells (hBMSCs) proliferation and differentiation, which in turn promotes bone regeneration in the distal femoral defect region of steroid\u2010associated osteonecrosis (SAON) rat model. Moreover, it is screened and demonstrated that PLGA\/BP scaffolds can promote osteogenic differentiation by transcriptomic analysis, and PLGA\/BP scaffolds promote osteogenic differentiation and mineralization by activating PI3K\u2010AKT\u00a0signaling pathway in hBMSC cells. 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