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However, the clinical translation of SDT is restricted seriously by the lack of high\u2010performance sonosensitizers. Herein, the distinct single atom iron (Fe)\u2010doped graphitic\u2010phase carbon nitride (C\n                    <jats:sub>3<\/jats:sub>\n                    N\n                    <jats:sub>4<\/jats:sub>\n                    ) semiconductor nanosheets (Fe\u2010C\n                    <jats:sub>3<\/jats:sub>\n                    N\n                    <jats:sub>4<\/jats:sub>\n                    NSs) are designed and engineered as chemoreactive sonosensitizers to effectively separate the electrons (e\n                    <jats:sup>\u2212<\/jats:sup>\n                    ) and holes (h\n                    <jats:sup>+<\/jats:sup>\n                    ) pairs, achieving high yields of ROS generation against melanoma upon ultrasound (US) activation. Especially, the single atom Fe doping not only substantially elevates the separation efficiency of the e\n                    <jats:sup>\u2212<\/jats:sup>\n                    \u2010h\n                    <jats:sup>+<\/jats:sup>\n                    pairs involved in SDT, but also can serve as high\u2010performance peroxidase mimetic enzyme to catalyze the Fenton reaction for generating abundant hydroxyl radicals, therefore synergistically augmenting the curative effect mediated by SDT. As verified by density functional theory simulation, the doping of Fe atom significantly promotes the charge redistribution in the C\n                    <jats:sub>3<\/jats:sub>\n                    N\n                    <jats:sub>4<\/jats:sub>\n                    \u2010based NSs, which improves their synergistic SDT\/chemodynamic activities. Both the in vitro and in vivo assays demonstrate that Fe\u2010C\n                    <jats:sub>3<\/jats:sub>\n                    N\n                    <jats:sub>4<\/jats:sub>\n                    NSs feature an outstanding antitumor effect by aggrandizing the sono\u2010chemodynamic effect. This work illustrates a unique single\u2010atom doping strategy for ameliorating the sonosensitizers, and also effectively expands the innovative anticancer\u2010therapeutic applications of semiconductor\u2010based inorganic sonosensitizers.\n                  <\/jats:p>","DOI":"10.1002\/advs.202302579","type":"journal-article","created":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T23:18:35Z","timestamp":1686179915000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":79,"title":["Single Atom Iron\u2010Doped Graphic\u2010Phase C\n                    <sub>3<\/sub>\n                    N\n                    <sub>4<\/sub>\n                    Semiconductor Nanosheets for Augmented Sonodynamic Melanoma Therapy Synergy with Endowed Chemodynamic Effect"],"prefix":"10.1002","volume":"10","author":[{"given":"Guiying","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Ultrasonography Hainan General Hospital\/Hainan Affiliated Hospital of Hainan Medical University  570311 Haikou P. 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